Koontz J W, Goodman S
Biochem Biophys Res Commun. 1985 Sep 16;131(2):815-20. doi: 10.1016/0006-291x(85)91312-9.
The liver specific enzyme, tyrosine aminotransferase, can be induced by glucocorticoids, cAMP analogs, or insulin. Each of these different inducing agents is believed to act through a separate pathway. The tumor promoting phorbol esters have been reported to stimulate phosphorylation of the insulin receptor and thereby decrease the ability of insulin to induce tyrosine aminotransferase. Our results demonstrate that TPA will not only inhibit the insulin stimulated increase in tyrosine aminotransferase, but will also inhibit induction of the enzyme by glucocorticoids or by cAMP.
肝脏特异性酶——酪氨酸转氨酶，可被糖皮质激素、环磷酸腺苷类似物或胰岛素诱导。据信，这些不同的诱导剂各自通过独立的途径发挥作用。据报道，促肿瘤的佛波酯可刺激胰岛素受体的磷酸化，从而降低胰岛素诱导酪氨酸转氨酶的能力。我们的结果表明，佛波酯不仅会抑制胰岛素刺激引起的酪氨酸转氨酶增加，还会抑制糖皮质激素或环磷酸腺苷对该酶的诱导作用。
