Vraníková Barbora, Gajdziok Jan
Ceska Slov Farm. 2015 Nov;64(5):159-72.
Bioavailability increasing of poorly soluble drugs has become one of the main topics of modern pharmaceutical technology. Many methods based on the chemical modification, physical modification or new technological processes have been already used to improve bioavailability. Some of these methods (e.g. micronization, preparation of solid dispersions, formulation of an inclusion complex, etc.) have been for many years successfully used by pharmaceutical companies. On the other hand, methods such as liquisolid system and self-emulsifying drug delivery systems are still in the early stages of their development. It is expected that this novel methods could play a significant role in the preparation of modern dosage forms. The aim of this paper is to provide the summary of methods improving bioavailability of poorly soluble drugs used in the field of pharmaceutical technology.
提高难溶性药物的生物利用度已成为现代制药技术的主要课题之一。许多基于化学修饰、物理修饰或新工艺的方法已被用于提高生物利用度。其中一些方法（如微粉化、固体分散体的制备、包合物的制剂等）多年来已被制药公司成功使用。另一方面，液固系统和自乳化药物递送系统等方法仍处于发展的早期阶段。预计这些新方法将在现代剂型的制备中发挥重要作用。本文的目的是总结制药技术领域中用于提高难溶性药物生物利用度的方法。
