Godlewski C E, Boyd J N, Sherman W K, Anderson J L, Stoewsand G S
Cancer Lett. 1985 Sep 15;28(2):151-7. doi: 10.1016/0304-3835(85)90070-9.
The aim of the present study was to determine whether the liver cytosol detoxication enzymes, glutathione S-transferases (GSTases) as well as gamma-glutamyl transpeptidase (GGT) foci induced by aflatoxin B1 (AFB) were changed by feeding weanling rats diets containing brussels sprouts, a glucosinolate fraction of brussels sprouts (extract), or a non-glucosinolate fraction (residue). All 3 of these diets induced high levels of hepatic GSTase specific activity as compared to purified-basal diet fed control rats. The brussels sprouts and the extract treatments, but not the residue dietary treatment, inhibited hepatic GGT foci induced by AFB. Thus, glucosinolates and non-glucosinolate fractions of brussels sprouts induce hepatic enzymes involved in detoxication mechanisms but the non-glucosinolate compound(s) apparently are not involved in all chemical carcinogen metabolic processes.
本研究的目的是确定，给断奶大鼠喂食含有抱子甘蓝、抱子甘蓝的硫代葡萄糖苷组分（提取物）或非硫代葡萄糖苷组分（残渣）的日粮，是否会改变由黄曲霉毒素B1（AFB）诱导产生的肝细胞溶质解毒酶、谷胱甘肽S-转移酶（GST酶）以及γ-谷氨酰转肽酶（GGT）灶。与喂食纯化基础日粮的对照大鼠相比，所有这三种日粮均诱导出高水平的肝脏GST酶比活性。抱子甘蓝和提取物处理组，但不包括残渣日粮处理组，抑制了由AFB诱导产生的肝脏GGT灶。因此，抱子甘蓝的硫代葡萄糖苷和非硫代葡萄糖苷组分可诱导参与解毒机制的肝脏酶，但非硫代葡萄糖苷化合物显然并不参与所有化学致癌物的代谢过程。
