Chau Jennifer, Podadera Juan M, Young Alex C, Makara Mariano A
Am J Vet Res. 2017 Jul;78(7):828-839. doi: 10.2460/ajvr.78.7.828.
OBJECTIVE To evaluate the effect of gadoxetic acid (contrast) dose on biliary tract enhancement, determine the optimal time after contrast injection for CT image acquisition, and assess the feasibility of CT cholangiography in sedated dogs. ANIMALS 8 healthy dogs. PROCEDURES The study had 2 parts. In part 1, 4 dogs were anesthetized and underwent CT cholangiography twice. Gadoxetic acid was administered IV at a low dose (0.025 mmol/kg) for the first procedure and high dose (0.3 mmol/kg) for the second procedure. Serial CT scans were obtained at predetermined times after contrast injection. In part 2, 4 dogs were sedated and underwent CT angiography 85 minutes after IV administration of the high contrast dose. Contrast enhancement of the biliary tract on all scans was objectively assessed by measurement of CT attenuation and qualitatively assessed by use of a subjective 4-point scoring system by 3 independent reviewers. All measurements were compared over time and between contrast doses for the dogs of part 1. Subjective measurements were compared between the sedated dogs of part 2 and anesthetized dogs of part 1. RESULTS Enhancement of the biliary tract was positively associated with contrast dose and time after contrast injection. Optimal enhancement was achieved 65 minutes after contrast injection. Subjective visualization of most biliary structures did not differ significantly between sedated and anesthetized dogs. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated CT cholangiography with gadoxetic acid was feasible in sedated dogs. The high contrast dose provided better visualization of biliary structures than the low dose; CT scans should be obtained 65 minutes after contrast injection.
目的 评估钆塞酸（造影剂）剂量对胆道强化的影响，确定注射造影剂后进行CT图像采集的最佳时间，并评估在镇静犬中进行CT胆管造影的可行性。 动物 8只健康犬。 方法 本研究分为2部分。在第1部分中，4只犬麻醉后接受2次CT胆管造影。第1次检查静脉注射低剂量（0.025 mmol/kg）钆塞酸，第2次检查静脉注射高剂量（0.3 mmol/kg）钆塞酸。在注射造影剂后的预定时间进行系列CT扫描。在第2部分中，4只犬镇静后在静脉注射高剂量造影剂85分钟后接受CT血管造影。通过测量CT衰减对所有扫描图像上的胆道造影增强进行客观评估，并由3名独立的评估者使用主观4分评分系统进行定性评估。对第1部分犬的所有测量值随时间以及不同造影剂剂量之间进行比较。对第2部分镇静犬和第1部分麻醉犬的主观测量值进行比较。 结果 胆道强化与造影剂剂量及注射造影剂后的时间呈正相关。注射造影剂后65分钟达到最佳强化效果。镇静犬和麻醉犬之间大多数胆道结构的主观可视化效果无显著差异。 结论及临床意义 结果表明，在镇静犬中使用钆塞酸进行CT胆管造影是可行的。高剂量造影剂比低剂量能更好地显示胆道结构；应在注射造影剂后65分钟进行CT扫描。
