一种分析复杂剂量反应关系的新方法：章鱼胺对水蛭莱迪希神经元作用的多变量研究
A new approach to the analysis of complex dose-response relationships: a multivariate study of octopamine action on the leech Leydig neurone.
作者信息
Dean J A, Ford M G, Leake L D
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(1):165-70. doi: 10.1016/0742-8413(85)90225-7.
Octopamine (OA) hyperpolarizes leech Leydig neurones but response amplitudes and thresholds vary. Associations between response, OA dose and other variables [initial resting potential, action potential (AP) frequency and amplitude, temperature, microelectrode resistance, position of ganglion along nerve cord, animal, treatment order] were examined using canonical correlation. A complex response was expressed by summing changes in membrane potential and AP frequency over 2 min of OA treatment. Only dose and ganglion position influenced this response. One significant canonical variate related dose to immediate changes in membrane potential and summed changes in AP frequency throughout the OA effect. Response to OA was greater in cells in posterior ganglia.
章鱼胺（OA）使水蛭间质细胞超极化，但反应幅度和阈值各不相同。使用典型相关分析研究了反应、OA剂量与其他变量[初始静息电位、动作电位（AP）频率和幅度、温度、微电极电阻、神经节沿神经索的位置、动物、处理顺序]之间的关联。通过在OA处理的2分钟内对膜电位变化和AP频率变化求和来表达复杂反应。只有剂量和神经节位置影响这种反应。一个显著的典型变量将剂量与整个OA效应期间膜电位的即时变化以及AP频率的总和变化联系起来。后神经节中的细胞对OA的反应更大。
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