Kurtz Theodore W, DiCarlo Stephen E, Pravenec Michal, Morris R Curtis
aDepartment of Laboratory Medicine, University of California, San Francisco, California bDepartment of Physiology, Wayne State University, Detroit, Michigan, USA cInstitute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic dDepartment of Medicine, University of California, San Francisco, California, USA.
J Hypertens. 2017 Nov;35(11):2214-2225. doi: 10.1097/HJH.0000000000001458.
: Recently, the American Heart Association (AHA) published a scientific statement on salt sensitivity of blood pressure which emphasized a decades old conceptual framework for the pathogenesis of this common disorder. Here we examine the extent to which the conceptual framework for salt sensitivity emphasized in the AHA Statement accommodates contemporary findings and views of the broader scientific community on the pathogenesis of salt sensitivity. In addition, we highlight alternative conceptual frameworks and important contemporary theories of salt sensitivity that are little discussed in the AHA Statement. We suggest that greater consideration of conceptual frameworks and theories for salt sensitivity beyond those emphasized in the AHA Statement may help to advance understanding of the pathogenesis of salt-induced increases in blood pressure and, in consequence, may lead to improved approaches to preventing and treating this common disorder.
最近，美国心脏协会（AHA）发表了一份关于血压盐敏感性的科学声明，该声明强调了一个存在数十年的关于这种常见疾病发病机制的概念框架。在此，我们探讨AHA声明中所强调的盐敏感性概念框架在多大程度上与更广泛科学界关于盐敏感性发病机制的当代研究结果和观点相契合。此外，我们突出了AHA声明中较少讨论的盐敏感性替代概念框架和重要当代理论。我们认为，更多地考虑AHA声明中未强调的盐敏感性概念框架和理论，可能有助于推进对盐诱导血压升高发病机制的理解，进而可能带来预防和治疗这种常见疾病的改进方法。
