Korndewal Marjolein J, Oudesluys-Murphy Anne Marie, Kroes Aloys C M, Vossen Ann C T M, de Melker Hester E
From the *Centre for Infectious Diseases, Epidemiology and Surveillance, National Institute for Public Health and the Environment, Bilthoven, the Netherlands, †Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands, and ‡Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.
Pediatr Infect Dis J. 2017 Dec;36(12):1141-1147. doi: 10.1097/INF.0000000000001663.
Congenital cytomegalovirus (cCMV) infection is the most common congenital infection worldwide and can lead to long-term impairments such as developmental delay. It is currently unknown how this affects the daily life of children and their parents. Children For this study, children with cCMV were identified by testing stored dried blood spots of 31,484 five-year-old children born in 2008 in the Netherlands. Parents of 133 children with cCMV and 274 children without cCMV participated and filled in questionnaires on the child's development, the child's and parents' quality of life, care provided for the children and consequences of cCMV on daily life. School performance reports at 6 years of age were also investigated. Children with cCMV had delays in general and expressive language development more often, and they attended physical therapists more frequently than children without cCMV. School performance of children with cCMV and symptoms at birth was poorer than that of cCMV-negative children with similar symptoms at birth. The quality of life of children with long-term impairment was lower in children with cCMV than those without cCMV. Parents of children with cCMV and long-term impairments reported more physical and concentration problems than parents of children without cCMV. These findings indicate that cCMV has a considerable impact not only on the child's development and school performance but also on the daily life of children and their parents. The care for children with cCMV should therefore include support for motor and speech-language development as well as family-centered care.
先天性巨细胞病毒（cCMV）感染是全球最常见的先天性感染，可导致发育迟缓等长期损害。目前尚不清楚这如何影响儿童及其父母的日常生活。在本研究中，通过检测2008年出生于荷兰的31484名五岁儿童储存的干血斑，确定了患有cCMV的儿童。133名患有cCMV的儿童和274名未患cCMV的儿童的父母参与了研究，并填写了关于儿童发育、儿童和父母生活质量、为儿童提供的护理以及cCMV对日常生活影响的问卷。还调查了6岁时的学校成绩报告。与未患cCMV的儿童相比，患cCMV的儿童更常出现一般和表达性语言发育迟缓，并且更频繁地接受物理治疗师的治疗。出生时患有cCMV且有症状的儿童的学校成绩比出生时具有类似症状的cCMV阴性儿童差。患有cCMV且有长期损害的儿童的生活质量低于未患cCMV的儿童。患有cCMV且有长期损害的儿童的父母报告的身体和注意力问题比未患cCMV的儿童的父母更多。这些发现表明，cCMV不仅对儿童的发育和学校成绩有相当大的影响，而且对儿童及其父母的日常生活也有相当大影响。因此，对患有cCMV的儿童的护理应包括对运动和言语语言发育的支持以及以家庭为中心的护理。
