儿童产前寨卡病毒暴露后第三年的神经发育。
Neurodevelopment in the third year of life in children with antenatal ZIKV-exposure.
机构信息
Universidade de São Paulo. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Reabilitação. São Paulo, SP, BR.
Universidade de São Paulo. Faculdade de Medicina. Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional. São Paulo, SP, BR.
出版信息
Rev Saude Publica. 2021 Apr 23;55:15. doi: 10.11606/s1518-8787.2021055002798. eCollection 2021.
Abstract
We report cognitive, language and motor neurodevelopment, assessed by the Bayley-III test, in 31 non-microcephalic children at age 3 with PCR-confirmed maternal Zika virus exposure (Rio de Janeiro, 2015-2016). Most children had average neurodevelopmental scores, however, 8 children (26%) presented delay in some domain. Language was the most affected: 7 children (22.6%) had a delay in this domain (2 presenting severe delay). Moderate delay was detected in the cognitive (3.2%) and motor (10%) domains. Maternal illness in the third trimester of pregnancy and later gestational age at birth were associated with higher Bayley-III scores. Zika-exposed children require long-term follow-up until school age.
摘要
我们报告了 31 名非小头畸形且经 PCR 确诊的母源性寨卡病毒暴露的儿童在 3 岁时的认知、语言和运动神经发育情况，这些儿童通过贝利 III 测试进行评估（2015-2016 年，里约热内卢）。大多数儿童的神经发育评分均处于平均水平，但有 8 名儿童（26%）在某些领域存在发育迟缓。语言是受影响最严重的领域：7 名儿童（22.6%）在该领域存在延迟（2 名儿童存在严重延迟）。认知（3.2%）和运动（10%）领域也存在中度延迟。妊娠晚期母体患病和较晚的出生胎龄与较高的贝利 III 评分相关。寨卡病毒暴露的儿童需要在上学年龄之前进行长期随访。
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