Vanneste Sven, Ost Jan, Van Havenbergh Tony, De Ridder Dirk
School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, United States of America.
BRAI2N, Sint Augustinus Hospital Antwerp, Antwerp, Belgium.
PLoS One. 2017 Jun 26;12(6):e0178516. doi: 10.1371/journal.pone.0178516. eCollection 2017.
The exact mechanism underlying fibromyalgia is unknown, but increased facilitatory modulation and/or dysfunctional descending inhibitory pathway activity are posited as possible mechanisms contributing to sensitization of the central nervous system. The primary goal of this study is to identify a fibromyalgia neural circuit that can account for these abnormalities in central pain. The second goal is to gain a better understanding of the functional connectivity between the default and the executive attention network (salience network plus dorsal lateral prefrontal cortex) in fibromyalgia. We examine neural activity associated with fibromyalgia (N = 44) and compare these with healthy controls (N = 44) using resting state source localized EEG. Our data support an important role of the pregenual anterior cingulate cortex but also suggest that the degree of activation and the degree of integration between different brain areas is important. The inhibition of the connectivity between the dorsal lateral prefrontal cortex and the posterior cingulate cortex on the pain inhibitory pathway seems to be limited by decreased functional connectivity with the pregenual anterior cingulate cortex. Our data highlight the functional dynamics of brain regions integrated in brain networks in fibromyalgia patients.
纤维肌痛的确切潜在机制尚不清楚，但促进性调制增加和/或下行抑制通路功能障碍被认为是导致中枢神经系统敏化的可能机制。本研究的主要目标是确定一个能够解释这些中枢性疼痛异常的纤维肌痛神经回路。第二个目标是更好地理解纤维肌痛患者默认网络与执行注意力网络（突显网络加上背外侧前额叶皮层）之间的功能连接。我们使用静息态源定位脑电图检查与纤维肌痛相关的神经活动（N = 44），并将这些与健康对照者（N = 44）进行比较。我们的数据支持膝前扣带回皮层的重要作用，但也表明不同脑区之间的激活程度和整合程度很重要。疼痛抑制通路上背外侧前额叶皮层与后扣带回皮层之间的连接抑制似乎因与膝前扣带回皮层功能连接减少而受限。我们的数据突出了纤维肌痛患者脑网络中整合脑区的功能动态。
