食用芡欧鼠尾草（Salvia hispanica L）可改善胰岛素抵抗大鼠心脏中葡萄糖代谢异常的状况，并减少胶原蛋白沉积的增加。
Dietary Salba (Salvia hispanica L) improves the altered metabolic fate of glucose and reduces increased collagen deposition in the heart of insulin-resistant rats.
作者信息
Creus Agustina, Benmelej Adriana, Villafañe Noelia, Lombardo Yolanda B
机构信息
Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria El Pozo cc 242, 3000 Santa Fe, Argentina.
Department of Morphology, School of Biochemistry, University of Litoral, Ciudad Universitaria El Pozo cc 242, 3000 Santa Fe, Argentina.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:30-39. doi: 10.1016/j.plefa.2017.06.002. Epub 2017 Jun 5.
This study reports the effects of dietary Salba (chia) seeds on the mechanisms underlying impaired glucose metabolism in the heart of dyslipemic insulin-resistant rats fed a sucrose-rich diet (SRD). Wistar rats were fed a SRD for 3 months. Afterwards, half the animals continued with the SRD; in the other half's diet chia seeds replaced corn oil (CO) for three months (SRD+chia). In the control group, corn starch replaced sucrose. The replacement of CO by chia seeds in the SRD restored the activities of key enzymes involved in heart glucose metabolism decreasing fatty acid oxidation. Chia seeds normalized insulin stimulated GLUT-4 transporter, the abundance of IRS-1 and pAMPK, changed the profile of fatty acid phospholipids, reduced left-ventricle collagen deposition and normalized hypertension and dyslipidemia. New evidence is provided concerning the effects of dietary chia seeds in improving the altered metabolic fate of glucose in the heart of dyslipemic insulin-resistant rats.
本研究报告了膳食奇亚籽对喂食富含蔗糖饮食（SRD）的血脂异常胰岛素抵抗大鼠心脏中葡萄糖代谢受损机制的影响。将Wistar大鼠喂食SRD 3个月。之后，一半动物继续喂食SRD；另一半动物的饮食中奇亚籽替代了玉米油（CO），持续3个月（SRD+奇亚籽）。在对照组中，玉米淀粉替代了蔗糖。在SRD中用奇亚籽替代CO可恢复心脏葡萄糖代谢中关键酶的活性，减少脂肪酸氧化。奇亚籽使胰岛素刺激的GLUT-4转运蛋白、IRS-1和pAMPK的丰度正常化，改变了脂肪酸磷脂的谱，减少了左心室胶原沉积，并使高血压和血脂异常正常化。提供了关于膳食奇亚籽改善血脂异常胰岛素抵抗大鼠心脏中葡萄糖代谢改变的新证据。
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