妊娠期间母体血浆 n-3 和 n-6 多不饱和脂肪酸与胎儿健康特征：胎儿生长速度、出生体重和妊娠持续时间。
Maternal plasma n-3 and n-6 polyunsaturated fatty acids during pregnancy and features of fetal health: Fetal growth velocity, birth weight and duration of pregnancy.
机构信息
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
出版信息
Clin Nutr. 2018 Aug;37(4):1367-1374. doi: 10.1016/j.clnu.2017.06.010. Epub 2017 Jun 10.
BACKGROUND & AIMS: Maternal fatty acids are essential for fetal growth and development. Here, we examine associations between maternal mid-pregnancy plasma n-3 and n-6 polyunsaturated fatty acids (PUFAs) and fetal health determined by fetal growth velocity, birth weight and duration of pregnancy.
METHODS
Participants were 6974 pregnant women and their infants from a population-based birth cohort, the Generation R Study. Maternal plasma n-3:n-6 PUFA ratio and n-3 and n-6 PUFA percentage in glycerophospholipids in mid-pregnancy were related to fetal growth velocity calculated from repeatedly measured weight, length and head circumference, birth weight, and duration of pregnancy.
RESULTS
A higher maternal mid-pregnancy n-3:n-6 PUFA ratio was associated with a higher growth velocity of the fetal weight (β = 0.082 SD-score/week, 95% CI 0.055; 0.108, P < 0.001), length (β = 0.085 SD-score/week, 95% CI 0.052; 0.119, P < 0.001); and head (β = 0.055 SD-score/week, 95% CI 0.019; 0.091, P = 0.003). We also observed positive associations between n-3:n-6 PUFA ratio and birth weight (β = 0.76 SD-score, 95% CI 0.22; 1.29, P = 0.006), and duration of pregnancy (β = 1.32 weeks, 95% CI 0.24; 2.40, P = 0.02).
CONCLUSIONS
These results are consistent with the hypothesis that a higher n-3:n-6 PUFA ratio is important for fetal health.
背景与目的
母体脂肪酸对胎儿生长发育至关重要。本研究旨在探讨孕妇妊娠中期血浆中 n-3 和 n-6 多不饱和脂肪酸（PUFA）与通过胎儿生长速度、出生体重和妊娠持续时间来确定的胎儿健康之间的关联。
方法
本研究纳入了一项基于人群的出生队列研究——“生育队列研究”中的 6974 名孕妇及其婴儿。在妊娠中期，通过反复测量体重、长度和头围来计算胎儿生长速度，检测母体血浆中 n-3:n-6 PUFA 比值和 n-3 和 n-6 甘油磷脂中的 PUFA 百分比与胎儿生长速度、出生体重和妊娠持续时间的关系。
结果
较高的母体妊娠中期 n-3:n-6 PUFA 比值与胎儿体重（β=0.082 标准差/周，95%CI 0.055；0.108，P<0.001）、长度（β=0.085 标准差/周，95%CI 0.052；0.119，P<0.001）和头围（β=0.055 标准差/周，95%CI 0.019；0.091，P=0.003）的生长速度更快有关。我们还观察到 n-3:n-6 PUFA 比值与出生体重（β=0.76 标准差，95%CI 0.22；1.29，P=0.006）和妊娠持续时间（β=1.32 周，95%CI 0.24；2.40，P=0.02）呈正相关。
结论
这些结果与 n-3:n-6 PUFA 比值较高对胎儿健康很重要的假说一致。
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