Check J H, Goldberg B B, Kurtz A, Adelson H G, Dietterich C
Int J Fertil. 1985;30(2):61-3.
Therapy with human menopausal gonadotropin (HMG) conventionally has been monitored by estrogen measurements. Pelvic sonography may offer a more accurate method of monitoring HMG therapy. In this study 67 anovulatory patients were treated with HMG until at least one follicle had a diameter of 17 mm. The serum estradiol level was noted at the time a mature follicle was achieved. There was a correlation between the ultrasound data and the serum estradiol range in 57% of the cases. However, in 24% it was necessary to push the estradiol level above the allowable maximum of 2000 pg/mL. Twenty percent of the patients attained a 17-mm follicle before reaching the minimum required estradiol level of 500 pg/mL. Sonographic monitoring should improve the efficacy of HMG therapy.
传统上，人绝经期促性腺激素（HMG）治疗一直通过雌激素测量进行监测。盆腔超声检查可能提供一种更准确的监测HMG治疗的方法。在本研究中，67例无排卵患者接受HMG治疗，直至至少有一个卵泡直径达到17毫米。在达到成熟卵泡时记录血清雌二醇水平。57%的病例中超声数据与血清雌二醇范围之间存在相关性。然而，在24%的病例中，有必要将雌二醇水平推高至允许的最大值2000 pg/mL以上。20%的患者在达到所需的最低雌二醇水平500 pg/mL之前就有一个17毫米的卵泡。超声监测应能提高HMG治疗的疗效。
