Gumpel E, Moore A S, Simpson D J, Hoffmann K L, Taylor D P
Brisbane Veterinary Specialist Centre, Albany Creek, Queensland, Australia.
Animal Referral Hospital, Homebush, New South Wales, Australia.
Aust Vet J. 2017 Jul;95(7):227-231. doi: 10.1111/avj.12602.
Olfactory neuroblastoma is a rare malignancy of the nasal cavity in dogs that is thought to arise from specialised sensory neuroendocrine olfactory cells derived from the neural crest.
An 8-year-old dog was presented for reclusiveness and pacing. On CT and MRI, a contract-enhancing mass was disclosed within the rostral fossa, extending caudally from the cribriform plate into the left nasal sinus. Surgical excision was performed and the diagnosis was histological grade III (Hyams grading scheme) olfactory neuroblastoma. Based on human CT criteria this was high stage (modified Kadish stage C). Surgical excision was incomplete and was followed by curative-intent radiation therapy using a linear accelerator to a total dose of 48 Gy.
The dog survived 20 months after diagnosis. Although olfactory neuroblastoma is a rare tumour in dogs, aggressive local therapy may allow for prolonged survival, even when the tumour is advanced.
嗅神经母细胞瘤是犬鼻腔罕见的恶性肿瘤，被认为起源于神经嵴衍生的特殊感觉神经内分泌嗅觉细胞。
一只8岁犬因孤僻和踱步前来就诊。CT和MRI检查发现，在颅前窝有一个强化的肿块，从筛板向尾侧延伸至左鼻窦。进行了手术切除，组织学诊断为III级（海姆斯分级系统）嗅神经母细胞瘤。根据人类CT标准，这是晚期（改良卡迪什分期C期）。手术切除不完全，随后使用直线加速器进行根治性放疗，总剂量为48 Gy。
该犬在诊断后存活了20个月。尽管嗅神经母细胞瘤在犬中是罕见肿瘤，但积极的局部治疗可能使生存期延长，即使肿瘤已处于晚期。
