Balakrishnan Lakshmi, Rennie Donna, Dosman James, Pahwa Punam, Karunanayake Chandima, Hagel Louise, Lawson Joshua
Department of Community Health and Epidemiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Respirology. 2017 Oct;22(7):1320-1328. doi: 10.1111/resp.13097. Epub 2017 Jun 27.
The relationship between farming exposures and pulmonary function in a rural paediatric population was evaluated.
Baseline data collection records of the Saskatchewan Rural Health Study (SRHS), a population-based study, were used. A subset of children (6-14 years old) participated in clinical testing, including anthropometric measures and pulmonary function testing (PFT), using spirometry (n = 584). PFTs followed ATS criteria and all statistical analyses were controlled for age, sex and height.
Among clinical testing participants, 47.5% were females and 54.5% were farm dwelling. Of those living on farms, 77.5% were livestock farms. Mean percent predicted value (PPV) for forced expiratory volume in 1 s (FEV ) and forced vital capacity (FVC) among children living on a farm were 104.8% and 105.4%, respectively. Mean PPV for FEV and FVC among children not living on a farm were 102.7% and 101.4%, respectively. After adjustment, higher FEV (=0.079, SE = 0.033, P = 0.03) and FVC (=0.110, SE = 0.039, P = 0.006) were seen among children living on a farm. A trend towards lower FEV /FVC ratio (-0.013, SE = 0.008, P = 0.09) among children living on a farm was seen compared with children not living on a farm. Higher FVC and lower FEV /FVC ratio were seen in children who regularly emptied grain bins (P < 0.05). Trends towards higher FEV (P = 0.14) and FVC (P = 0.08) were also seen with children living on a farm in the first year of life. Since the majority of the population was Caucasian (91%), the results were not race-corrected.
We addressed the lack of knowledge regarding the association between lung function and rural exposures, and found that differences in lung function were seen between children living on a farm and not living on a farm in rural areas and certain farming activities, specifically emptying grain bins, where lung function was generally better in those living on a farm.
评估农村儿童群体中农业暴露与肺功能之间的关系。
使用基于人群的萨斯喀彻温农村健康研究（SRHS）的基线数据收集记录。一部分儿童（6 - 14岁）参与了临床测试，包括人体测量和肺功能测试（PFT），采用肺活量测定法（n = 584）。PFT遵循美国胸科学会（ATS）标准，所有统计分析均对年龄、性别和身高进行了控制。
在临床测试参与者中，47.5%为女性，54.5%居住在农场。在那些居住在农场的儿童中，77.5%是畜牧场。居住在农场的儿童中，1秒用力呼气容积（FEV）和用力肺活量（FVC）的平均预测值百分比（PPV）分别为104.8%和105.4%。不住在农场的儿童中，FEV和FVC的平均PPV分别为102.7%和101.4%。调整后，居住在农场的儿童中FEV（=0.079，标准误=0.033，P = 0.03）和FVC（=0.110，标准误=0.039，P = 0.006）更高。与不住在农场的儿童相比，居住在农场的儿童中FEV/FVC比值有降低的趋势（-0.013，标准误=0.008，P = 0.09）。经常清空谷仓的儿童中FVC更高且FEV/FVC比值更低（P < 0.05）。在一岁时居住在农场的儿童中也观察到FEV（P = 0.14）和FVC（P = 0.08）升高的趋势。由于大多数人群是白种人（91%），结果未进行种族校正。
我们解决了关于肺功能与农村暴露之间关联的知识空白，发现农村地区居住在农场和不住在农场的儿童之间以及某些农业活动（特别是清空谷仓）中肺功能存在差异，居住在农场的儿童肺功能总体上更好。
