Ma Zheng, Cai Hongfei, Cui Youbin
Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, China.
Tumour Biol. 2017 Jun;39(6):1010428317711313. doi: 10.1177/1010428317711313.
Esophageal neuroendocrine neoplasms are rare. With the improvement and popularization of diagnostic methods, the morbidity statistics have increased annually in recent years. There are currently no treatment guidelines for esophageal neuroendocrine neoplasms, and surgery is the only cure. This usually involves radical surgery when the tumor is limited to the primary site or when only regional lymph node metastasis occurs. Surgical treatment is key to treating esophageal neuroendocrine neoplasms, but combined treatment with chemotherapy and radiotherapy can significantly improve patient survival. The effect of radiotherapy alone on this disease is poor. However, targeted endocrine therapy can improve endocrine hormone symptoms. The prognosis of patients with esophageal neuroendocrine neoplasms is mainly determined by the pathological stage. With the development of molecular biology techniques, the combination of targeted drugs and traditional chemotherapy is expected to provide novel ideas and directions for the treatment of esophageal neuroendocrine neoplasms in the coming years. In this article, the status of esophageal neuroendocrine tumor treatments was reviewed in detail.
食管神经内分泌肿瘤较为罕见。随着诊断方法的改进与普及，近年来其发病率统计呈逐年上升趋势。目前尚无食管神经内分泌肿瘤的治疗指南，手术是唯一的治愈方法。当肿瘤局限于原发部位或仅发生区域淋巴结转移时，通常采用根治性手术。手术治疗是食管神经内分泌肿瘤治疗的关键，但化疗和放疗联合治疗可显著提高患者生存率。单纯放疗对该病效果不佳。然而，靶向内分泌治疗可改善内分泌激素症状。食管神经内分泌肿瘤患者的预后主要取决于病理分期。随着分子生物学技术的发展，靶向药物与传统化疗联合有望在未来几年为食管神经内分泌肿瘤的治疗提供新的思路和方向。本文详细综述了食管神经内分泌肿瘤的治疗现状。
