布洛芬与水溶性对磺酸钠杯[4]芳烃的络合：药物递送应用的潜在候选物。
Complexation of ibuprofen with water soluble p-sulfonatocalix [4]arene: A potential candidate for drug delivery applicatio.
作者信息
Khokhar Tahira S, Memon Shahabuddin, Panhwar Qadeer K, Memon Fakhar N, Memon Ayaz A, Samejo Muhammad Qasim, Muneer Saba, Tulu Metin
机构信息
National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan.
Dr. M. A. Kazi, Institute of Chemistry, University of Sindh, Jamshoro, Pakistan.
出版信息
Pak J Pharm Sci. 2017 May;30(3):783-788.
Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. δG, ΔH and δS have been found as -24.09 KJ/mol, 0.012 KJ/mol and 0.12 KJ/mol. K, respectively. The results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier.
评估了布洛芬与水溶性对磺酸钠杯[4]芳烃（3）的络合作用。两种分子均表现出主客体型络合。通过紫外可见光谱和傅里叶变换红外光谱确定了pH值、络合物化学计量比和结合常数。3与布洛芬的最大络合作用发生在pH 2时。稳定性常数（9.897）表明，由于对磺酸钠杯[4]芳烃的重要作用，形成了有利的络合物，而热力学参数，即δG、ΔH和δS分别为-24.09 KJ/mol、0.012 KJ/mol和0.12 KJ/mol·K。结果表明，3在特定条件下具有运载药物的能力，可作为载体用于药物递送。
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