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小儿心脏手术中经食管超声心动图检查术后严重上气道梗阻:一项回顾性分析

Severe Upper Airway Obstruction After Intraoperative Transesophageal Echocardiography in Pediatric Cardiac Surgery: A Retrospective Analysis.

作者信息

Michel Jörg, Hofbeck Michael, Schineis Christian, Kumpf Matthias, Heimberg Ellen, Magunia Harry, Schmid Eckhard, Schlensak Christian, Blumenstock Gunnar, Neunhoeffer Felix

机构信息

1Department of Pediatric Cardiology, Pulmology, and Pediatric Intensive Care Medicine, University Children's Hospital Tuebingen, Tuebingen, Germany. 2Department of Anesthesiology and Intensive Care Medicine, University Hospital Tuebingen, Tuebingen, Germany. 3Department of Thoracic, Cardiac and Vascular Surgery, University Hospital Tuebingen, Tuebingen, Germany. 4Institute for Clinical Epidemiology and Applied Biometry, Eberhard Karls University Tuebingen, Tuebingen, Germany.

出版信息

Pediatr Crit Care Med. 2017 Oct;18(10):924-930. doi: 10.1097/PCC.0000000000001252.

Abstract

OBJECTIVES

The aim of this study was to evaluate if there is a correlation between the use of intraoperative transesophageal echocardiography and an increased rate of extubation failure and to find other risk factors for severe upper airway obstructions after pediatric cardiac surgery.

DESIGN

Retrospective analysis.

SETTING

Cardiac PICU.

PATIENTS

Patients 24 months old or younger who underwent surgery for congenital heart disease with cardiopulmonary bypass were retrospectively enrolled and divided into two groups depending on whether they received an intraoperative transesophageal echocardiography or not. We analyzed all cases of early reintubations within 12 hours after extubation due to a documented upper airway obstruction.

INTERVENTION

None.

MEASUREMENTS AND MAIN RESULTS

From a total of 424 patients, 12 patients (2.8%) met our criteria of early reintubation due to upper airway obstruction. Ten of 207 children in the transesophageal echocardiography group had to be reintubated, whereas only two of the 217 children in the control group had to be reintubated (4.8% vs 0.9%; p = 0.018). Logistic regression analysis showed a significant correlation between use of intraoperative transesophageal echocardiography and extubation failure (odds ratio, 5.64; 95% CI, 1.18-27.05; p = 0.030). There was no significant relationship among sex (odds ratio, 4.53; 95% CI, 0.93-22.05; p = 0.061), weight (odds ratio, 1.07; 95% CI, 0.82-1.40; p = 0.601), duration of surgery (odds ratio, 1.04; 95% CI, 0.74-1.44; p = 0.834), duration of mechanical ventilation (odds ratio, 1.00; 95% CI, 0.99-1.00; p = 0.998), and occurrence of trisomy 21 (odds ratio, 3.47; 95% CI, 0.83-14.56; p = 0.089).

CONCLUSIONS

Although the benefits of intraoperative transesophageal echocardiography during pediatric cardiac surgery are undisputed, it may be one factor which could increase the rate of severe upper airway obstruction after extubation with the need for reintubation. We suggest to take precautions before extubating high-risk patients, especially in young male children with genetic abnormalities after cardiac surgery with cardiopulmonary bypass.

摘要

目的

本研究旨在评估术中经食管超声心动图的使用与拔管失败率增加之间是否存在相关性,并找出小儿心脏手术后严重上气道梗阻的其他风险因素。

设计

回顾性分析。

地点

心脏重症监护病房。

患者

对24个月及以下接受先天性心脏病体外循环手术的患者进行回顾性纳入,并根据是否接受术中经食管超声心动图检查分为两组。我们分析了所有因记录在案的上气道梗阻在拔管后12小时内早期再次插管的病例。

干预措施

无。

测量指标及主要结果

在总共424例患者中,12例(2.8%)符合我们因上气道梗阻而早期再次插管的标准。经食管超声心动图检查组的207名儿童中有10名需要再次插管,而对照组的217名儿童中只有2名需要再次插管(4.8%对0.9%;p = 0.018)。逻辑回归分析显示术中经食管超声心动图的使用与拔管失败之间存在显著相关性(比值比,5.64;95%置信区间,1.18 - 27.05;p = 0.030)。性别(比值比,4.53;95%置信区间,0.93 - 22.05;p = 0.061)、体重(比值比,1.07;95%置信区间,0.82 - 1.40;p = 0.601)、手术持续时间(比值比,1.04;95%置信区间,0.74 - 1.44;p = 0.834)、机械通气持续时间(比值比,1.00;95%置信区间,0.99 - 1.00;p = 0.998)和21三体综合征的发生情况(比值比,3.47;95%置信区间,0.83 - 14.56;p = 0.089)之间均无显著关系。

结论

尽管术中经食管超声心动图在小儿心脏手术中的益处无可争议,但它可能是导致拔管后严重上气道梗阻并需要再次插管发生率增加的一个因素。我们建议在对高危患者拔管前采取预防措施,尤其是在接受体外循环心脏手术后有遗传异常的年幼男性儿童中。

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