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囊内髋部骨折的患者生存率及手术再次干预预测因素

Patient survival and surgical re-intervention predictors for intracapsular hip fractures.

作者信息

González Quevedo David, Mariño Iskandar Tamimi, Sánchez Siles Juan Manuel, Escribano Esther Romero, Granero Molina Esther Judith, Enrique David Bautista, Smoljanović Tomislav, Pareja Francisco Villanueva

机构信息

Department of Orthopedic Surgery and Traumatology, Regional University Hospital of Málaga, Spain.

Department of Orthopedic Surgery and Traumatology, Regional University Hospital of Málaga, Spain.

出版信息

Injury. 2017 Aug;48(8):1831-1836. doi: 10.1016/j.injury.2017.06.014. Epub 2017 Jun 20.

Abstract

BACKGROUND

Choosing between total hip replacement (THR) and partial hip replacement (PHR) for patients with intracapsular hip fractures is often based on subjective factors. Predicting the survival of these patients and risk of surgical re-intervention is essential to select the most adequate implant.

METHODS

We conducted a retrospective cohort study on mortality of patients over 70 years with intracapsular hip fractures who were treated between January 2010 and December 2013, with either PHR or THR. Patients' information was withdrawn from our local computerized database. The age-adjusted Charlson comorbidity index (ACCI) and American Society of Anesthesiologists (ASA) score were calculated for all patients. The patients were followed for 2 years after surgery. Survival and surgical re-intervention rates were compared between the two groups using a Multivariate Cox proportional hazard model.

RESULTS

A total of 356 individuals were included in this study. At 2 years of follow-up, 221 (74.4%) of the patients with ACCI score≤7 were still alive, in contrast to only 20 (29.0%) of those with ACCI score>7. In addition, 201 (76.2%) of the patients with ASA score≤3 were still alive after 2 years, compared to 30 (32.6%) of individuals with ASA >3. Patients with the ACCI score>7, and ASA score>3 had a significant increase in all-cause 2-year mortality (adjusted hazard ratio of 3.2, 95% CI 2.2-4.6; and 3.12, 95% CI 2.2-4.5, respectively). Patients with an ASA score>3 had a quasi-significant increase in the re-intervention risk (adjusted hazard ratio 2.2, 95% CI 1.0-5.1). The sensitivity, specificity, positive predictive value and negative predictive values of ACCI in predicting 2-year mortality were 39.2%, 91.1%, 71%, and 74.4%, respectively. On the other hand, the sensitivity, specificity, positive predictive value and negative predictive values of ASA score in predicting 2-year mortality were 49.6%, 79.1%, 67.4%, and 76.1%, respectively.

CONCLUSIONS

Both ACCI and ASA scales were able to predict the 2-year survival of patients with intracapsular hip fractures. The ASA scale was also able to predict the risk of re-intervention in these patients.

摘要

背景

对于囊内髋部骨折患者,在全髋关节置换术(THR)和半髋关节置换术(PHR)之间做出选择通常基于主观因素。预测这些患者的生存率和手术再次干预的风险对于选择最合适的植入物至关重要。

方法

我们对2010年1月至2013年12月期间接受PHR或THR治疗的70岁以上囊内髋部骨折患者的死亡率进行了一项回顾性队列研究。患者信息从我们当地的计算机数据库中提取。计算所有患者的年龄调整Charlson合并症指数(ACCI)和美国麻醉医师协会(ASA)评分。患者术后随访2年。使用多变量Cox比例风险模型比较两组的生存率和手术再次干预率。

结果

本研究共纳入356例个体。在2年的随访中,ACCI评分≤7的患者中有221例(74.4%)仍存活,而ACCI评分>7的患者中只有20例(29.0%)存活。此外,ASA评分≤3的患者中有201例(76.2%)在2年后仍存活,而ASA>3的个体中有30例(32.6%)存活。ACCI评分>7和ASA评分>3的患者全因2年死亡率显著增加(调整后的风险比分别为3.2,95%CI 2.2 - 4.6;以及3.12,95%CI 2.2 - 4.5)。ASA评分>3的患者再次干预风险有近乎显著的增加(调整后的风险比2.2,95%CI 1.0 - 5.1)。ACCI在预测2年死亡率方面的敏感性、特异性、阳性预测值和阴性预测值分别为39.2%、91.1%、71%和74.4%。另一方面,ASA评分在预测2年死亡率方面的敏感性、特异性、阳性预测值和阴性预测值分别为49.6%、79.1%、67.4%和76.1%。

结论

ACCI和ASA量表都能够预测囊内髋部骨折患者的2年生存率。ASA量表还能够预测这些患者的再次干预风险。

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