Institut National de Recherche et de Sécurité, 1 rue du Morvan CS 60027, 54519 Vandoeuvre Cedex, France.
Institut National de Recherche et de Sécurité, 1 rue du Morvan CS 60027, 54519 Vandoeuvre Cedex, France.
Reprod Toxicol. 2017 Sep;72:106-114. doi: 10.1016/j.reprotox.2017.06.133. Epub 2017 Jun 24.
Pregnant Sprague-Dawley rats were administered the insecticide α-cypermethrin at doses of 0.1, 1, 5, or 10mg/kg/day, or di-isobutyl phthalate (DIBP) at 250mg/kg/day, by gavage, from gestation day (GD) 13 to 19. Testicular testosterone production and the expression of several key genes related to cholesterol and androgen synthesis and transport were assessed in GD 19 male fetuses. Dams treated with 10mg/kg/day of α-cypermethrin showed clinical signs of neurotoxicity and reduced body weight gain. α-Cypermethrin had no significant effect on post-implantation loss, fetal weight, incidence of male fetuses per litter, or anogenital distance of the male fetuses. In the fetal testes, mRNA expressions of HMG-CoA synthase and reductase, SRB1, StAR, P450scc, 3βHSD, P450 17A1, and 17βHSD were not affected by exposure to α-cypermethrin. Testosterone production by the fetal testis was significantly reduced at 5 and 10mg/kg/day of α-cypermethrin, although to a much smaller extent than in DIBP-exposed fetuses.
妊娠 Sprague-Dawley 大鼠经灌胃给予α-氯氰菊酯 0.1、1、5 或 10mg/kg/天，或邻苯二甲酸二异丁酯（DIBP）250mg/kg/天，从妊娠第 13 天至第 19 天。在妊娠第 19 天雄性胎儿中评估了睾丸睾酮的产生和与胆固醇及雄激素合成和转运相关的几个关键基因的表达。经灌胃给予 10mg/kg/天α-氯氰菊酯的孕鼠表现出神经毒性的临床体征和体重增加减少。α-氯氰菊酯对着床后丢失、胎儿体重、每窝雄性胎儿的发生率或雄性胎儿的肛殖距无显著影响。在胎儿睾丸中，HMG-CoA 合酶和还原酶、SRB1、StAR、P450scc、3βHSD、P45017A1 和 17βHSD 的 mRNA 表达不受α-氯氰菊酯暴露的影响。尽管程度远小于 DIBP 暴露的胎儿，但 5 和 10mg/kg/天的α-氯氰菊酯使胎儿睾丸的睾酮产生显著减少。
