Beglinger Svetlana, Drewe Jürgen, Christ-Crain Mirjam
Department of Endocrinology, Diabetes and Metabolism, University Hospital of Basel, 4031 Basel, Switzerland.
Department of Clinical Pharmacology, University Hospital of Basel, 4031 Basel, Switzerland.
J Biomark. 2017;2017:4737082. doi: 10.1155/2017/4737082. Epub 2017 Jun 1.
Several studies have investigated copeptin as a prognostic marker of different acute diseases and as a diagnostic marker in disorders of water and salt homeostasis. However, no data of the normal circadian rhythm of copeptin in healthy subjects are available.
To investigate the circadian rhythm of copeptin in healthy subjects under standardized conditions.
19 healthy volunteers aged 18 to 53 years, male and female, were studied in a prospective observational study. In all 19 participants, blood samples for copeptin were taken in regular intervals of 30 minutes for 24 hours after a fasting period of minimum 8 hours.
The mean values of copeptin showed a circadian rhythm, similar to that described for AVP release, with a trend towards higher levels (5.9 ± 1 pmol/L) at night and early morning between 4 am and 6 am and lowest levels (2.3 ± 0.2 pmol/L) in the late afternoon between 5 pm and 7 pm. This finding was only observed in individuals with initial higher copeptin levels, whereas in individuals with lower basal copeptin levels no circadian rhythm was observed.
There is evidence for a circadian rhythm in copeptin release during 24 hours, however, of minor extent. These findings suggest that copeptin levels can be determined irrespectively of the time of the day.
多项研究已将 copeptin 作为不同急性疾病的预后标志物以及水盐稳态紊乱的诊断标志物进行了调查。然而，尚无健康受试者中 copeptin 正常昼夜节律的数据。
在标准化条件下研究健康受试者中 copeptin 的昼夜节律。
在一项前瞻性观察性研究中，对 19 名年龄在 18 至 53 岁之间的健康志愿者（男女皆有）进行了研究。在所有 19 名参与者中，在至少禁食 8 小时后，每隔 30 分钟定期采集 copeptin 的血样，共采集 24 小时。
copeptin 的平均值显示出昼夜节律，类似于抗利尿激素（AVP）释放所描述的节律，夜间和凌晨 4 点至 6 点之间水平有升高趋势（5.9±1 pmol/L），下午 5 点至 7 点之间水平最低（2.3±0.2 pmol/L）。这一发现仅在初始 copeptin 水平较高的个体中观察到，而在基础 copeptin 水平较低的个体中未观察到昼夜节律。
有证据表明 24 小时内 copeptin 释放存在昼夜节律，但程度较小。这些发现表明，无论一天中的什么时间，都可以测定 copeptin 水平。
