Callegari Emma T, Garland Suzanne M, Gorelik Alexandra, Chiang Cherie Y, Wark John D
1 Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
2 34361 Murdoch Childrens Research Institute , Parkville, VIC, Australia.
Ann Clin Biochem. 2018 May;55(3):328-340. doi: 10.1177/0004563217719734. Epub 2017 Dec 21.
Background Bone turnover markers (BTMs) may provide insight into bone health in young women, but have been little studied in this demographic. We aimed to explore the association between body composition, hormonal contraception, bone mineral density and biochemical parameters and BTMs in young women. Methods Participants were community-dwelling females aged 16-25 years, living in Victoria, Australia. Carboxy-terminal cross-linking telopeptide of type 1 collagen (CTX) and total procollagen type 1 N-propeptide (P1NP) were analysed on the Roche Elecsys automated analyzer. A total of 305 were evaluated, after excluding participants with medical conditions or medications (except hormonal contraceptives), which may affect bone metabolism. Results Median (Q1, Q3) BTM values were 540 (410, 690) ng/L for CTX and 61.7 (46.2, 83.7) µg/L for P1NP. Serum CTX and P1NP were inversely associated with chronological age ( P < 0.001), transferrin ( P < 0.020) and serum dehydroepiandrosterone sulphate concentration ( P < 0.001). BTM values were up to 22% lower in combined oral contraceptive (COC) pill users ( P < 0.001). Serum CTX was inversely associated with per cent body fat ( P = 0.009) and tibial cortical volumetric bone mineral density (vBMD; P = 0.003). Serum P1NP concentrations were 23 µg/L higher in participants who reported using an osteopath in the previous year ( P = 0.007). Conclusions These data suggest that BTMs are influenced by age, COC use, body composition, iron status and hormonal profiles. Higher CTX values were associated with lower tibial cortical vBMD. Examining BTMs in relation to interventions aimed at improving bone health in young women is warranted.
背景 骨转换标志物（BTMs）可能有助于了解年轻女性的骨骼健康状况，但在这一人群中对此研究较少。我们旨在探讨年轻女性的身体成分、激素避孕、骨密度和生化参数与BTMs之间的关联。方法 参与者为居住在澳大利亚维多利亚州的16 - 25岁社区女性。使用罗氏电化学发光自动分析仪分析1型胶原羧基末端交联肽（CTX）和1型前胶原氨基端前肽（P1NP）。在排除可能影响骨代谢的疾病或药物（激素避孕药除外）的参与者后，共评估了305人。结果 CTX的中位数（Q1，Q3）BTM值为540（410，690）ng/L，P1NP为61.7（46.2，83.7）μg/L。血清CTX和P1NP与实际年龄（P < 0.001）、转铁蛋白（P < 0.020）和血清硫酸脱氢表雄酮浓度（P < 0.001）呈负相关。复方口服避孕药（COC）使用者的BTM值低达22%（P < 0.001）。血清CTX与体脂百分比（P = 0.009）和胫骨皮质骨体积密度（vBMD；P = 0.003）呈负相关。报告前一年看过整骨医生的参与者血清P1NP浓度高23 μg/L（P = 0.007）。结论 这些数据表明BTMs受年龄、COC使用、身体成分、铁状态和激素水平的影响。较高的CTX值与较低的胫骨皮质vBMD相关。有必要研究BTMs与旨在改善年轻女性骨骼健康的干预措施之间的关系。
