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一名胰肾移植受者膀胱腺癌与BK病毒感染的关联

Association of bladder adenocarcinoma and BK virus infection in a pancreatico-renal transplant recipient.

作者信息

Fernández Rivera Constantino, Alonso Hernández Ángel, Mosquera Reboredo Juan, Rodríguez Gómez Ignacio

机构信息

Service of Nephrology.

Service of Pathology.

出版信息

NDT Plus. 2010 Jun;3(3):300-302. doi: 10.1093/ndtplus/sfq042. Epub 2010 Apr 13.

DOI:10.1093/ndtplus/sfq042
PMID:28657060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5477964/
Abstract

Viral infection has been related to post-transplantation tumour development, particularly Epstein-Barr virus, human papillomavirus, hepatitis B and C viruses, and herpes virus 8. Recently, BK virus (BKV) has emerged as an important cause of tumour formation in solid organ transplant recipients. BKV oncogenic potential relates to the ability to inactivate the functions of tumour suppression proteins p53 and pRB family, and induction of chromosomal aberrations. We report a case of urinary bladder adenocarcinoma in a pancreatico-renal transplant recipient which was diagnosed 2 years after BKV infection. Immunohistochemical staining for SV-40 was positive in neoplastic cells but negative in non-neoplastic cells.

摘要

病毒感染与移植后肿瘤的发生有关，尤其是爱泼斯坦-巴尔病毒、人乳头瘤病毒、乙型和丙型肝炎病毒以及疱疹病毒8。最近，BK病毒（BKV）已成为实体器官移植受者肿瘤形成的一个重要原因。BKV的致癌潜力与使肿瘤抑制蛋白p53和pRB家族功能失活以及诱导染色体畸变的能力有关。我们报告了一例胰腺-肾脏移植受者发生膀胱腺癌的病例，该病例在感染BKV两年后被诊断出来。肿瘤细胞中SV-40免疫组化染色呈阳性，而非肿瘤细胞中呈阴性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/5477964/9aeb27346795/sfq042fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/5477964/e9c1f59eb481/sfq042fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/5477964/9aeb27346795/sfq042fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/5477964/e9c1f59eb481/sfq042fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebb/5477964/9aeb27346795/sfq042fig2.jpg

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The oncogenic potential of BK-polyomavirus is linked to viral integration into the human genome.BK多瘤病毒的致癌潜力与病毒整合到人类基因组中有关。
J Pathol. 2015 Nov;237(3):379-89. doi: 10.1002/path.4584. Epub 2015 Aug 19.

本文引用的文献

1
High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection.一名感染BK病毒的肾移植受者发生的高级别尿路上皮癌。
NDT Plus. 2009 Jun;2(3):246-9. doi: 10.1093/ndtplus/sfp025. Epub 2009 Feb 26.
2
The decade of polyomavirus BK-associated nephropathy: state of affairs.多瘤病毒BK相关性肾病十年：现状
Transplantation. 2009 Mar 15;87(5):621-30. doi: 10.1097/TP.0b013e318197c17d.
3
Collecting duct carcinoma arising in association with BK nephropathy post-transplantation in a pediatric patient. A case report with immunohistochemical and in situ hybridization study.
一名儿科患者移植后并发BK肾病相关的集合管癌。一项免疫组织化学和原位杂交研究的病例报告。
Pediatr Transplant. 2008 Aug;12(5):600-5. doi: 10.1111/j.1399-3046.2007.00855.x.
4
Polyomavirus in renal transplantation: a hot problem.肾移植中的多瘤病毒：一个热点问题。
Transplantation. 2008 Apr 15;85(7 Suppl):S42-8. doi: 10.1097/TP.0b013e318169c794.
5
Successful treatment of BK viremia using reduction in immunosuppression without antiviral therapy.在未进行抗病毒治疗的情况下，通过降低免疫抑制成功治疗BK病毒血症。
Transplantation. 2008 Mar 27;85(6):850-4. doi: 10.1097/TP.0b013e318166cba8.
6
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.人多瘤病毒BKV通过pRb/E2F途径转录激活DNA甲基转移酶1。
Oncogene. 2006 May 4;25(19):2727-35. doi: 10.1038/sj.onc.1209266.
7
A longitudinal molecular surveillance study of human polyomavirus viremia in heart, kidney, liver, and pancreas transplant patients.
J Infect Dis. 2005 Oct 15;192(8):1349-54. doi: 10.1086/466532. Epub 2005 Sep 14.
8
Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations.肾移植中多瘤病毒相关性肾病：多学科分析与建议
Transplantation. 2005 May 27;79(10):1277-86. doi: 10.1097/01.tp.0000156165.83160.09.
9
Malignancy in renal transplantation.肾移植中的恶性肿瘤
J Am Soc Nephrol. 2004 Jun;15(6):1582-8. doi: 10.1097/01.asn.0000126194.77004.9b.
10
Oncogenic transformation by BK virus and association with human tumors.BK病毒的致癌转化及其与人类肿瘤的关联。
Oncogene. 2003 Aug 11;22(33):5192-200. doi: 10.1038/sj.onc.1206550.