Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University , Wuhu 241000, China.
Org Lett. 2017 Jul 7;19(13):3636-3639. doi: 10.1021/acs.orglett.7b01559. Epub 2017 Jun 28.
Copper-catalyzed ortho-acyloxylation of the sp C-H bond of aryl amides with carboxylic acids is reported. Benzoic acids, cinnamic acids, and aliphatic acids can be involved, and the desired products were obtained in moderate to good yields. This procedure is compatible with a wide range of functional groups and heteroarenes without the use of any ligands or additives. This method provides an operationally simple approach for the synthesis of benzoate and cinnamate.
报道了铜催化的芳酰胺 sp^C-H 键与羧酸的邻位酰氧基化反应。苯甲酸、肉桂酸和脂肪族酸都可以参与反应，目标产物以中等至良好的产率得到。该方法在不使用任何配体或添加剂的情况下，对多种官能团和杂芳烃都具有兼容性。这种方法为合成苯甲酸酯和肉桂酸酯提供了一种操作简单的方法。
