Bizzarri Nicolò, Vellone Valerio Gaetano, Parodi Luca, Calanni Fraccono Luana, Ghirardi Valentina, Costantini Sergio, Menada Mario Valenzano, Sala Paolo
a Academic Unit of Obstetrics and Gynecology , IRCCS AOU San Martino - IST , Genoa , Italy.
b Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) , University of Genoa , Genoa , Italy.
J Obstet Gynaecol. 2017 Nov;37(8):975-981. doi: 10.1080/01443615.2017.1318269. Epub 2017 Jun 28.
Vulvar cancer accounts for 5% of the female genital tract cancers. Cutaneous metastases from vulvar cancer are extremely rare and for this reason, it can be difficult to reach a diagnosis with a consequent delay in the treatment. A systematic literature review of articles on this subject was conducted through a MEDLINE-based search for articles published in English or French. To date, 16 cases (including ours unpublished) of cutaneous metastasis from vulvar cancer have been reported. Cutaneous metastasis can occur from any stage of vulvar cancer, even after a short period. Different treatments have been described but none of them seems to be more effective. In all reported cases the prognosis was very poor. Every time a vulvar cancer survivor shows a suspicious cutaneous lesion, this should be biopsied to exclude skin relapse. Impact statement Cutaneous metastases from vulvar cancer are extremely rare and due to its rarity, a standard treatment has not been established yet. Cutaneous metastasis can occur from any stage of vulvar cancer, even after a short period. In all the reported cases, the prognosis was very poor. Every time a vulvar cancer survivor shows a suspect cutaneous lesion, this should be biopsied to exclude skin relapse.
外阴癌占女性生殖道癌症的5%。外阴癌的皮肤转移极为罕见，因此，可能难以做出诊断，从而导致治疗延误。通过基于MEDLINE搜索以英文或法文发表的文章，对关于该主题的文章进行了系统的文献综述。迄今为止，已报道了16例（包括我们未发表的病例）外阴癌皮肤转移。外阴癌的任何阶段都可能发生皮肤转移，即使在短时间后也可能出现。已经描述了不同的治疗方法，但似乎没有一种更有效。在所有报道的病例中，预后都非常差。每当外阴癌幸存者出现可疑的皮肤病变时，都应进行活检以排除皮肤复发。影响声明：外阴癌的皮肤转移极为罕见，由于其罕见性，尚未确立标准治疗方法。外阴癌的任何阶段都可能发生皮肤转移，即使在短时间后也可能出现。在所有报道的病例中，预后都非常差。每当外阴癌幸存者出现可疑的皮肤病变时，都应进行活检以排除皮肤复发。
