Gyr K, Beglinger C, Stalder G A
Schweiz Med Wochenschr. 1985 Sep 21;115(38):1299-306.
The pancreas has both exocrine and endocrine components. The exocrine component of the pancreas manufactures, stores, and packages digestive enzymes for digestion of food, whereas the endocrine secretes hormones that regulate the metabolism and utilization of the absorbed nutrient components. Both components are closely related, not only anatomically but also functionally. The available evidence to support the concept of a close interrelationship of endocrine and exocrine pancreatic function is summarized. It is shown that the endocrine part exerts a profound effect upon the digestive activities of the organ, and that impairment of endocrine function, such as diabetes, severely affects the exocrine component of the gland. Furthermore, dysfunction of the exocrine gland, as in chronic pancreatitis, progressively disturbs the function of the islet cell hormones. The interactions are governed by a complicated control system, the details of which are not yet clarified. As in any partnership, dysfunction of one partner severely affects the other and vice versa.
胰腺具有外分泌和内分泌成分。胰腺的外分泌成分制造、储存和包装用于食物消化的消化酶，而内分泌成分则分泌调节吸收的营养成分的代谢和利用的激素。这两种成分不仅在解剖学上密切相关，在功能上也是如此。总结了支持胰腺内分泌和外分泌功能密切相互关系这一概念的现有证据。结果表明，内分泌部分对该器官的消化活动有深远影响，而内分泌功能受损，如糖尿病，会严重影响腺体的外分泌成分。此外，外分泌腺功能障碍，如慢性胰腺炎，会逐渐扰乱胰岛细胞激素的功能。这些相互作用由一个复杂的控制系统调节，其细节尚未阐明。就像任何伙伴关系一样，一方功能障碍会严重影响另一方，反之亦然。
