Van Rooyen J M, Offermeier J
S Afr Med J. 1985 Oct 26;Suppl:10-3.
At present several benzodiazepines are available for clinical use. Pharmacological and clinical studies have failed to show qualitative differences between them. The main variations among individual benzodiazepines are in their pharmacokinetics and metabolism. The differences in the rates of absorption, volumes of distribution, distribution half-lives, compartmental kinetics, metabolism and elimination half-lives between individual benzodiazepines are reviewed. These influence the selection of a particular benzodiazepine for a specific patient or condition. Guidelines for particular clinical situations are provided.
目前有几种苯二氮䓬类药物可供临床使用。药理学和临床研究未能显示它们之间存在质的差异。各个苯二氮䓬类药物的主要差异在于其药代动力学和代谢。本文综述了各个苯二氮䓬类药物在吸收速率、分布容积、分布半衰期、房室动力学、代谢和消除半衰期方面的差异。这些差异会影响针对特定患者或病情选择特定的苯二氮䓬类药物。本文提供了针对特定临床情况的指导原则。
