发作性睡病、多发性硬化症与HLA-DQB1*06:02之间存在关联吗？

Is there a relationship between narcolepsy, multiple sclerosis and HLA-DQB1*06:02?

作者信息

Lorenzoni Paulo José, Werneck Lineu Cesar, Crippa Ana Christina de Souza, Zanatta Alessandra, Kay Cláudia S Kamoi, Silvado Carlos Eduardo S, Scola Rosana Herminia

机构信息

Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Medicina Interna, Serviço de Neurologia, Curitiba PR, Brasil.

出版信息

Arq Neuropsiquiatr. 2017 Jun;75(6):345-348. doi: 10.1590/0004-282X20170063.

DOI:10.1590/0004-282X20170063

PMID:28658402

Abstract

We studied multiple sclerosis (MS) patients with the HLA-DQB106:02 allele and compared them with MS patients who did not carry the HLA-DQB106:02 allele. We analyzed clinical and neurophysiological criteria for narcolepsy in six MS patients with HLA-DQB106:02, compared with 12 MS patients who were HLA-DQB106:02 non-carriers. Only two patients with HLA-DQB106:02 allele scored higher than 10 on the Epworth Sleepiness Scale. Polysomnography recording parameters and the multiple sleep latency test showed an absence of narcolepsy in the study group. Our study suggested no significant correlation between narcolepsy, MS and HLA-DQB106:02. The HLA-DQB1*06:02 allele alone was not sufficient to cause MS patients to develop narcolepsy.

摘要

我们研究了携带HLA - DQB106:02等位基因的多发性硬化症（MS）患者，并将他们与未携带该等位基因的MS患者进行比较。我们分析了6名携带HLA - DQB106:02的MS患者发作性睡病的临床和神经生理学标准，并与12名未携带HLA - DQB106:02的MS患者进行比较。只有两名携带HLA - DQB106:02等位基因的患者在爱泼沃斯思睡量表上得分高于10分。多导睡眠图记录参数和多次睡眠潜伏期测试显示研究组中不存在发作性睡病。我们的研究表明发作性睡病、MS与HLA - DQB106:02之间无显著相关性。仅HLA - DQB106:02等位基因不足以使MS患者患上发作性睡病。