Bedolla-Barajas Martín, López-Hernández Juan Carlos, García-Padilla Lourdes Fabiola, Morales-Romero Jaime, Velarde-Rivera Fernando Antonio, Robles-Figueroa Martín, Ortiz-Peregrina José Raúl
Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Servicio de Alergia e Inmunología Clínica, Guadalajara, Jalisco, México.
Rev Alerg Mex. 2017 Apr-Jun;64(2):178-187. doi: 10.29262/ram.v64i2.255.
Hypovitaminosis D has been associated with various chronic diseases such as infections, autoimmune diseases, chronic obstructive pulmonary disease, cancer and asthma Objective: The objective at hand is to determine the prevalence of vitamin D (VD) insufficiency and deficiency in adults with allergic asthma.
Objective: The objective at hand is to determine the prevalence of vitamin D (VD) insufficiency and deficiency in adults with allergic asthma.
Through a cross-sectional study, we analyzed corresponding data amongst 135 patients. VD concentration was categorized as sufficient (≥ 30 ng/mL), insufficient (21-29 ng/mL), and deficient (≤ 20 ng/mL). The level of VD deficiency was measured through chemo-luminescence. We estimated the prevalence of VD alterations and their respective confidence intervals at 95 % (CI 95 %).
Within the analyzed population, there were 99/135 women (73.3 %); the mean age was 34.5 ± 10.3 years. The mean concentration of VD was 17.9 ± 6.9 ng/mL and the median was 17 ng/mL. The prevalence of VD insufficiency and deficiency was 25.2 % (CI 95 %, 18.6-33.2 %) and 71.1 % (CI 95 %, 62.9-78.1 %), respectively; VD concentrations ≤ 10 ng/mL had 13.3 % (CI 95 %, 8.5-20.2 %) and ≥ 30 ng/mL at 3.7 % (CI 95 %: 1.4-8.6 %). When we contrasted the men to the women, the median concentration of VD did not differ significantly (16 ng/mL vs. 18 ng/mL, p = 0.71).
In this study, patients with allergic asthma had distinctively reduced VD concentration levels; future research will determine if and how VD affects the severity of asthma.
维生素D缺乏症与多种慢性疾病有关，如感染、自身免疫性疾病、慢性阻塞性肺疾病、癌症和哮喘。目的：目前的目标是确定过敏性哮喘成人中维生素D（VD）不足和缺乏的患病率。
目前的目标是确定过敏性哮喘成人中维生素D（VD）不足和缺乏的患病率。
通过一项横断面研究，我们分析了135例患者的相应数据。VD浓度分为充足（≥30 ng/mL）、不足（21 - 29 ng/mL）和缺乏（≤20 ng/mL）。通过化学发光法测量VD缺乏水平。我们估计了VD改变的患病率及其95%的置信区间（CI 95%）。
在分析的人群中，有99/135名女性（73.3%）；平均年龄为34.5±10.3岁。VD的平均浓度为17.9±6.9 ng/mL，中位数为17 ng/mL。VD不足和缺乏的患病率分别为25.2%（CI 95%，18.6 - 33.2%）和71.1%（CI 95%，62.9 - 78.1%）；VD浓度≤10 ng/mL的占13.3%（CI 95%，8.5 - 20.2%），≥30 ng/mL的占3.7%（CI 95%：1.4 - 8.6%）。当我们将男性与女性进行对比时，VD的中位数浓度没有显著差异（16 ng/mL对18 ng/mL，p = 0.71）。
在本研究中，过敏性哮喘患者的VD浓度水平明显降低；未来的研究将确定VD是否以及如何影响哮喘的严重程度。
