Gaur Komal, Ganguly Barna
Postgraduate Resident, Department of Pharmacology, Pramukhswami Medical College, Karamsad, Gujarat, India.
Professor and Head, Department of Pharmacology, Pramukhswami Medical College, Karamsad, Gujarat, India.
J Clin Diagn Res. 2017 May;11(5):FC15-FC18. doi: 10.7860/JCDR/2017/25459.9819. Epub 2017 May 1.
Antenatal corticosteroids play an important role in preventing Respiratory Distress Syndrome (RDS) but benefits related to time between corticosteroid administration and delivery need to be explored.
To observe the effect of betamethasone administration in pregnant women at risk of preterm delivery and on foetal parameters, in terms of development of RDS.
It was a prospective observational study on pregnant women at risk of preterm delivery who were administered a single dose 24 mg injection betamethasone. Outcome of 111 newborns of enrolled mothers was observed in terms of respiratory distress, Downe's and Silverman Anderson score, need of NICU admission and ventilation. Paired t-test was used to compare means of maternal parameters before and after betamethasone. Independent sample t-test for comparison of scores for respiratory distress in neonates was used.
There was a significant decrease in maternal haematological parameters like mean Red Blood Cell (RBC) and mean Platelet Count (PC) whereas increase in mean Total leucocyte Count (TC) after betamethasone administration. Out of 111 newborn babies, 71 were born within 24 hours and rest were born after 24 hours of betamethasone administration. Twelve out of 71 newborns who were born within 24 hours of betamethasone administration, developed RDS. Mean Downe's score and mean Silverman Anderson score in neonates born within 24 hours of injection administration were significantly higher than those born after 24 hours.
Betamethasone administration affects the haematological parameters in mothers in antenatal period nearing term. A minimum of 24 hours have to elapse between corticosteroid administration and delivery of the preterm for benefits to occur.
产前使用皮质类固醇在预防呼吸窘迫综合征（RDS）中起着重要作用，但皮质类固醇给药与分娩之间的时间间隔相关的益处有待探索。
观察倍他米松对有早产风险的孕妇的影响以及对胎儿参数的影响，就RDS的发展而言。
这是一项对有早产风险的孕妇进行的前瞻性观察研究，这些孕妇接受了单剂量24毫克的倍他米松注射。观察了111名登记母亲的新生儿的呼吸窘迫、唐恩评分和西尔弗曼-安德森评分、入住新生儿重症监护病房（NICU）的需求和通气情况。采用配对t检验比较倍他米松给药前后母亲参数的均值。采用独立样本t检验比较新生儿呼吸窘迫评分。
倍他米松给药后，母亲的血液学参数如平均红细胞（RBC）和平均血小板计数（PC）显著降低，而平均白细胞总数（TC）增加。在111名新生儿中，71名在24小时内出生，其余在倍他米松给药24小时后出生。在倍他米松给药后24小时内出生的71名新生儿中，有12名发生了RDS。注射给药后24小时内出生的新生儿的平均唐恩评分和平均西尔弗曼-安德森评分显著高于24小时后出生的新生儿。
倍他米松给药会影响接近足月的产前母亲的血液学参数。皮质类固醇给药与早产分娩之间至少需要间隔24小时才能产生益处。
