Zhao Zhiwei, Dong Zhanfei, Ming Jie, Liu Yan
a Image Center , Affiliated Tumor Hospital of Xinjiang Medical University , Urumqi , China.
Nat Prod Res. 2018 Jun;32(12):1455-1458. doi: 10.1080/14786419.2017.1346645. Epub 2017 Jun 29.
Alzheimer's disease is a severe neurodegenerative disease affecting elder worldwide and closely related to the neurotoxicity induced by amyloid β. To find efficient therapeutics, we have investigated the protective effects of cedrin from Cedrus deodara (Roxb.) G. Don on PC12 cells against the neurotoxicity induced by amyloid β. The results have shown the viability of PC12 cells injured by amyloid β can be improved by cedrin. Cedrin can reduce reacrive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content. Meanwhile, the loss of mitochondrial membrane potential and mitochondrial permeability transition pore opening in PC12 cells, and elevated Caspase-3 activity, downregulated Bcl-2 and upregulated Bax are meliorated. These results demonstrate the protective effect of cedrin is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. This investigation gives evidences for the application of cedrin in practice and further investigation in vivo.
阿尔茨海默病是一种严重的神经退行性疾病，影响着全球老年人，且与β-淀粉样蛋白诱导的神经毒性密切相关。为了寻找有效的治疗方法，我们研究了喜马拉雅雪松（Cedrus deodara (Roxb.) G. Don）中的雪松素对PC12细胞抗β-淀粉样蛋白诱导的神经毒性的保护作用。结果表明，雪松素可提高受β-淀粉样蛋白损伤的PC12细胞的活力。雪松素可减少活性氧的过量产生，增加超氧化物歧化酶的活性，并降低丙二醛含量。同时，PC12细胞线粒体膜电位的丧失和线粒体通透性转换孔的开放以及Caspase-3活性的升高、Bcl-2的下调和Bax的上调均得到改善。这些结果表明，雪松素的保护作用与抑制氧化应激、改善线粒体功能障碍和抑制细胞凋亡有关。本研究为雪松素在实际应用中的应用及进一步的体内研究提供了证据。
