Non-coding regulatory variations: the dark matter of pancreatic cancer genomics.
作者信息
Scarpa Aldo, Mafficini Andrea
机构信息
ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.
Department of Diagnostics and Public Health, Section of Anatomical Pathology, University and Hospital Trust of Verona, Verona, Italy.
出版信息
Gut. 2018 Mar;67(3):399-400. doi: 10.1136/gutjnl-2017-314310. Epub 2017 Jun 28.
Abstract
摘要
相似文献
1
Non-coding regulatory variations: the dark matter of pancreatic cancer genomics.非编码调控变异：胰腺癌基因组学的暗物质。
Gut. 2018 Mar;67(3):399-400. doi: 10.1136/gutjnl-2017-314310. Epub 2017 Jun 28.
2
Immunodeficiency in Pancreatic Adenocarcinoma with Diabetes Revealed by Comparative Genomics.比较基因组学揭示的伴发糖尿病的胰腺腺癌中的免疫缺陷。
Clin Cancer Res. 2017 Oct 15;23(20):6363-6373. doi: 10.1158/1078-0432.CCR-17-0250. Epub 2017 Jul 6.
3
[Multi-omic approaches reveal new therapeutic targets for the treatment of pancreatic cancer].[多组学方法揭示胰腺癌治疗的新靶点]
Med Sci (Paris). 2018 May;34(5):379-382. doi: 10.1051/medsci/20183405003. Epub 2018 Jun 13.
4
The genomic profile of pancreatic adenocarcinoma and its relationship to metastatic disease.胰腺腺癌的基因组图谱及其与转移性疾病的关系。
Exp Mol Pathol. 2016 Oct;101(2):172-175. doi: 10.1016/j.yexmp.2016.07.011. Epub 2016 Aug 3.
5
Expression profiles analysis of pancreatic cancer.胰腺癌表达谱分析。
Eur Rev Med Pharmacol Sci. 2013 Feb;17(3):311-7.
6
Phenome-genome association studies of pancreatic cancer: new targets for therapy and diagnosis.胰腺癌的表型-基因组关联研究：治疗与诊断的新靶点
Cancer Genomics Proteomics. 2015 Jan-Feb;12(1):9-19.
7
Critical role of laser microdissection for genetic, epigenetic and proteomic analyses in pancreatic cancer.激光显微切割在胰腺癌的遗传、表观遗传和蛋白质组学分析中的关键作用。
Expert Rev Mol Diagn. 2011 Sep;11(7):695-701. doi: 10.1586/erm.11.62.
8
Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma.胰腺导管腺癌中体细胞拷贝数增加相关基因的整合基因组、转录组和 RNA 干扰分析。
Pancreas. 2013 Aug;42(6):1016-26. doi: 10.1097/MPA.0b013e318287d043.
9
Advances in the Genetics and Biology of Pancreatic Cancer.胰腺癌的遗传学与生物学进展
Cancer J. 2017 Nov/Dec;23(6):315-320. doi: 10.1097/PPO.0000000000000286.
10
Pancreatic cancer: PDAC metastases show identical known driver gene mutations.胰腺癌：胰腺导管腺癌转移灶显示相同的已知驱动基因突变。
Nat Rev Gastroenterol Hepatol. 2017 Mar;14(3):138. doi: 10.1038/nrgastro.2017.9. Epub 2017 Jan 25.
引用本文的文献
1
Dark-matter matters: Discriminating subtle blood cancers using the darkest DNA.暗物质很重要：利用最暗的 DNA 区分微妙的血液癌症。
PLoS Comput Biol. 2019 Aug 30;15(8):e1007332. doi: 10.1371/journal.pcbi.1007332. eCollection 2019 Aug.
2
Cell Fusion in Human Cancer: The Dark Matter Hypothesis.细胞融合与人类癌症：暗物质假说。
Cells. 2019 Feb 7;8(2):132. doi: 10.3390/cells8020132.
本文引用的文献
1
Characterising -regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues.表征组织学正常和肿瘤来源的胰腺组织转录组中的调控变异。
Gut. 2018 Mar;67(3):521-533. doi: 10.1136/gutjnl-2016-313146. Epub 2017 Jun 20.
2
Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma.胰腺导管腺癌中的复发性非编码调控突变
Nat Genet. 2017 Jun;49(6):825-833. doi: 10.1038/ng.3861. Epub 2017 May 8.
3
Pancreatic Cancer Genetics.胰腺癌遗传学
Int J Biol Sci. 2016 Jan 28;12(3):314-25. doi: 10.7150/ijbs.15001. eCollection 2016.
4
Genomic analyses identify molecular subtypes of pancreatic cancer.基因组分析确定了胰腺癌的分子亚型。
Nature. 2016 Mar 3;531(7592):47-52. doi: 10.1038/nature16965. Epub 2016 Feb 24.
5
Cancer statistics, 2016.癌症统计数据，2016 年。
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30. doi: 10.3322/caac.21332. Epub 2016 Jan 7.
6
Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans.人类基因组学。基因型-组织表达（GTEx）试点分析：人类多组织基因调控
Science. 2015 May 8;348(6235):648-60. doi: 10.1126/science.1262110. Epub 2015 May 7.
7
Whole genomes redefine the mutational landscape of pancreatic cancer.全基因组重新定义了胰腺癌的突变格局。
Nature. 2015 Feb 26;518(7540):495-501. doi: 10.1038/nature14169.
8
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.预计 2030 年美国癌症发病与死亡人数：甲状腺癌、肝癌和胰腺癌带来的意外负担。
Cancer Res. 2014 Jun 1;74(11):2913-21. doi: 10.1158/0008-5472.CAN-14-0155.
9
Genome-wide sequencing to identify the cause of hereditary cancer syndromes: with examples from familial pancreatic cancer.全基因组测序鉴定遗传性癌症综合征的病因：以家族性胰腺癌为例。
Cancer Lett. 2013 Nov 1;340(2):227-33. doi: 10.1016/j.canlet.2012.11.008. Epub 2012 Nov 27.
10
Matrix eQTL: ultra fast eQTL analysis via large matrix operations.矩阵 eQTL：通过大型矩阵运算实现超快速 eQTL 分析。
Bioinformatics. 2012 May 15;28(10):1353-8. doi: 10.1093/bioinformatics/bts163. Epub 2012 Apr 6.
Zotero 插件