Slevin Finbar, Ermiş Ekin, Vaidyanathan Sriram, Sen Mehmet, Scarsbrook Andrew F, Prestwich Robin Jd
Department of Clinical Oncology, Yorkshire Cancer Centre, Leeds, UK.
Department of Radiology, Yorkshire Cancer Centre, Leeds, UK.
Clin Med Insights Oncol. 2017 Jun 14;11:1179554917713005. doi: 10.1177/1179554917713005. eCollection 2017.
The accuracy of response assessment positron emission tomography (PET)-computed tomography (CT) following radiotherapy with or without chemotherapy for laryngeal/hypopharyngeal squamous cell carcinoma is uncertain.
In all, 35 patients with laryngeal or hypopharyngeal squamous cell carcinoma who were treated between 2009 and 2014 with (chemo)radiotherapy were identified. The accuracy of response assessment PET-CT was made by correlation with clinical follow-up and pathological findings.
Of the 35 patients, 20 (57%) had an overall complete metabolic response. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for response assessment [18Fluorine]-fluoro-2-deoxy-d-glucose (FDG) PET-CT for primary and nodal sites, respectively, were 100%, 73%, 46%, and 100% and 83%, 95%, 83%, and 95%.
Response assessment FDG PET-CT following (chemo)radiotherapy for laryngeal and hypopharyngeal carcinomas has a high NPV for both primary site and lymph nodes and can be used to guide treatment decisions. The PPV of residual FDG uptake at the primary tumour site is limited and requires examination and biopsy confirmation.
对于喉/下咽鳞状细胞癌，在放疗联合或不联合化疗后，正电子发射断层扫描（PET）-计算机断层扫描（CT）进行疗效评估的准确性尚不确定。
共纳入了2009年至2014年间接受（化疗）放疗的35例喉或下咽鳞状细胞癌患者。通过与临床随访及病理结果的相关性来评估PET-CT疗效评估的准确性。
35例患者中，20例（57%）出现总体完全代谢缓解。[18氟]-氟-2-脱氧-D-葡萄糖（FDG）PET-CT对原发灶和转移淋巴结疗效评估的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）分别为100%、73%、46%和100%，以及83%、95%、83%和95%。
对于喉癌和下咽癌，（化疗）放疗后进行疗效评估的FDG PET-CT对原发灶和淋巴结均具有较高的NPV，可用于指导治疗决策。原发肿瘤部位残留FDG摄取的PPV有限，需要通过检查和活检来确认。
