The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Stanford University School of Medicine, Stanford, CA, USA.
Eur Eat Disord Rev. 2017 Sep;25(5):406-410. doi: 10.1002/erv.2526. Epub 2017 Jun 29.
This population-based retrospective cohort study sought to determine if anorexia nervosa (AN) is associated with a higher risk of urolithiasis. Nine thousand three hundred two females with AN were compared to 92 959 randomly selected age-matched and practice-matched females. Cox regression was used to estimate the hazard ratio (HR) for urolithiasis and evaluate effect modification by age. Twenty-three participants with AN (0.25%) developed urolithiasis compared with 154 unexposed participants (0.17%) over a median of 4 years of observation. The risk of urolithiasis varied significantly with age (interaction p = 0.02). AN was associated with a more than threefold higher risk of urolithiasis in females ≤25 years of age (HR 3.49, 95% CI: 1.56-7.81; p = 0.002), but not in females over 25 years (HR 1.18, 95% CI: 0.69-2.02; p = 0.54). The distribution of diagnosis codes for urolithiasis differed between groups (p = 0.04), with a higher proportion of codes for uric acid urolithiasis in the AN (16.2%) versus unexposed group (5.0%). Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
这项基于人群的回顾性队列研究旨在确定神经性厌食症（AN）是否与更高的尿路结石风险相关。将 9302 名女性 AN 患者与 92959 名年龄和实践相匹配的随机选择的女性进行比较。使用 Cox 回归估计尿路结石的风险比（HR），并评估年龄的效应修饰作用。23 名 AN 患者（0.25%）在中位 4 年的观察期间发生尿路结石，而 154 名未暴露的患者（0.17%）发生尿路结石。尿路结石的风险与年龄显著相关（交互作用 p = 0.02）。AN 与≤25 岁女性尿路结石的风险增加三倍以上相关（HR 3.49，95% CI：1.56-7.81；p = 0.002），但与 25 岁以上女性无关（HR 1.18，95% CI：0.69-2.02；p = 0.54）。两组尿路结石诊断代码的分布不同（p = 0.04），AN 组（16.2%）尿酸尿路结石的代码比例高于未暴露组（5.0%）。版权所有 © 2017 约翰威利父子公司和饮食失调协会。
