Department of Oncodermatology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France.
Department of Oral Medicine, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France.
J Med Virol. 2017 Nov;89(11):2055-2057. doi: 10.1002/jmv.24887. Epub 2017 Jul 25.
Oral lichen planus (OLP) is a chronic inflammatory disease considered as a CD8+ T lymphocyte-mediated autoimmune reaction, which may be triggered by undetermined virus. Recent reports have described the detection of Merkel cell polyomavirus (MCPyV) DNA in oral samples from healthy patients and in patients with different forms of oral cancers. We therefore investigated in a prospective way whether MCPyV was detectable in oral lesions of patients with active OLP. Our preliminary results do not support the hypothesis that OLP may be triggered by MCPyV infection. Further studies are needed to evaluate the involvement of other human polyomaviruses in OLP pathogenesis.
口腔扁平苔藓（OLP）是一种慢性炎症性疾病，被认为是一种 CD8+T 淋巴细胞介导的自身免疫反应，可能由未确定的病毒引发。最近的报告描述了在健康患者和不同形式的口腔癌患者的口腔样本中检测到 Merkel 细胞多瘤病毒（MCPyV）DNA。因此，我们以前瞻性的方式研究了 MCPyV 是否可在活动期 OLP 患者的口腔病变中检测到。我们的初步结果不支持 OLP 可能由 MCPyV 感染引发的假设。需要进一步的研究来评估其他人类多瘤病毒在 OLP 发病机制中的作用。
