Murphy M B
Int J Clin Pharmacol Res. 1985;5(5):287-91.
Calcium antagonists are the latest addition to the antihypertensive armamentarium. The evidence available suggests that they lower blood pressure at least as effectively as diuretics, beta-receptor blockers and other vasodilators. Nifedipine is as effective as hydralazine as a third-line drug. Both nifedipine and verapamil may be used alone as first-line therapy, but they are more expensive and probably cause more symptomatic side-effects than diuretics or beta-receptor blockers.
钙拮抗剂是抗高血压药物库中的最新成员。现有证据表明，它们降低血压的效果至少与利尿剂、β受体阻滞剂和其他血管扩张剂一样有效。硝苯地平作为三线药物与肼屈嗪效果相当。硝苯地平和维拉帕米都可单独用作一线治疗，但它们比利尿剂或β受体阻滞剂更昂贵，且可能引起更多有症状的副作用。
