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乳腺上皮极性与巨噬细胞浸润。

Mammary epithelial polarity and macrophage infiltration.

作者信息

Xu Ren

机构信息

Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.

Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.

出版信息

Macrophage (Houst). 2017;4. doi: 10.14800/Macrophage.1521. Epub 2017 Mar 13.

DOI:10.14800/Macrophage.1521
PMID:28664188
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5485912/
Abstract

Loss of epithelial cell polarity and inflammation are hallmarks of breast cancer development. Although the association between the disruption of tissue polarity and inflammation has been demonstrated, we know little about how these two events are coupled. Using the 3D co-culture model of mammary epithelial cells and monocytes, a recent study reveals a link between disruption of epithelial polarity and monocytes infiltration.

摘要

上皮细胞极性丧失和炎症是乳腺癌发展的标志。尽管组织极性破坏与炎症之间的关联已得到证实，但我们对这两个事件是如何关联的却知之甚少。最近一项研究利用乳腺上皮细胞和单核细胞的三维共培养模型，揭示了上皮极性破坏与单核细胞浸润之间的联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910b/5485912/9a51be70d433/nihms859787f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910b/5485912/9a51be70d433/nihms859787f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910b/5485912/9a51be70d433/nihms859787f1.jpg

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Macrophage (Houst). 2017;4. doi: 10.14800/Macrophage.1521. Epub 2017 Mar 13.
2
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本文引用的文献

1
Increased ROS production in non-polarized mammary epithelial cells induces monocyte infiltration in 3D culture.非极化乳腺上皮细胞中活性氧生成增加会在三维培养中诱导单核细胞浸润。
J Cell Sci. 2017 Jan 1;130(1):190-202. doi: 10.1242/jcs.186031. Epub 2016 Sep 21.
2
NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals.核因子κB通过阻止微环境信号整合来破坏三维组织极性。
Oncotarget. 2013 Nov;4(11):2010-20. doi: 10.18632/oncotarget.1451.
3
High-infiltration of tumor-associated macrophages predicts unfavorable clinical outcome for node-negative breast cancer.
肿瘤相关巨噬细胞高浸润预测淋巴结阴性乳腺癌不良临床结局。
PLoS One. 2013 Sep 30;8(9):e76147. doi: 10.1371/journal.pone.0076147. eCollection 2013.
4
Cell polarity as a regulator of cancer cell behavior plasticity.细胞极性作为调节癌细胞行为可塑性的因素。
Annu Rev Cell Dev Biol. 2012;28:599-625. doi: 10.1146/annurev-cellbio-092910-154244. Epub 2012 Aug 6.
5
The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients.肿瘤相关巨噬细胞存在于肿瘤基质中作为乳腺癌患者的预后标志物。
BMC Cancer. 2012 Jul 23;12:306. doi: 10.1186/1471-2407-12-306.
6
RORα suppresses breast tumor invasion by inducing SEMA3F expression.RORα 通过诱导 SEMA3F 表达抑制乳腺癌侵袭。
Cancer Res. 2012 Apr 1;72(7):1728-39. doi: 10.1158/0008-5472.CAN-11-2762. Epub 2012 Feb 20.
7
Tumour-infiltrating macrophages and clinical outcome in breast cancer.浸润肿瘤的巨噬细胞与乳腺癌的临床结局。
J Clin Pathol. 2012 Feb;65(2):159-63. doi: 10.1136/jclinpath-2011-200355. Epub 2011 Nov 2.
8
Laminin regulates PI3K basal localization and activation to sustain STAT5 activation.层粘连蛋白调节 PI3K 的基础定位和激活以维持 STAT5 的激活。
Cell Cycle. 2010 Nov 1;9(21):4315-22. doi: 10.4161/cc.9.21.13578. Epub 2010 Nov 10.
9
NF-kappaB as a critical link between inflammation and cancer.NF-κB 作为炎症和癌症之间的关键联系。
Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000141. doi: 10.1101/cshperspect.a000141.
10
Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ.分析导管原位癌肿瘤微环境中的基质特征。
Breast Cancer Res Treat. 2010 Sep;123(2):397-404. doi: 10.1007/s10549-009-0654-0. Epub 2009 Dec 1.