乳腺上皮极性与巨噬细胞浸润。
Mammary epithelial polarity and macrophage infiltration.
作者信息
Xu Ren
机构信息
Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.
Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.
出版信息
Macrophage (Houst). 2017;4. doi: 10.14800/Macrophage.1521. Epub 2017 Mar 13.
Loss of epithelial cell polarity and inflammation are hallmarks of breast cancer development. Although the association between the disruption of tissue polarity and inflammation has been demonstrated, we know little about how these two events are coupled. Using the 3D co-culture model of mammary epithelial cells and monocytes, a recent study reveals a link between disruption of epithelial polarity and monocytes infiltration.
上皮细胞极性丧失和炎症是乳腺癌发展的标志。尽管组织极性破坏与炎症之间的关联已得到证实，但我们对这两个事件是如何关联的却知之甚少。最近一项研究利用乳腺上皮细胞和单核细胞的三维共培养模型，揭示了上皮极性破坏与单核细胞浸润之间的联系。
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