Mrugala Maciej M, Ruzevick Jacob, Zlomanczuk Piotr, Lukas Rimas V
Departments of Neurological Surgery, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Departments of Neurology, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Curr Oncol Rep. 2017 Aug;19(8):53. doi: 10.1007/s11912-017-0611-8.
Electric fields are known to produce biological effects. Depending on specific frequency, they can stimulate healing, directly damage tissues, or produce anti-mitotic activity. Frequencies of 100-300 KHz have been shown to disrupt mitosis and lead to cellular death. Growth of cancer cell lines, both in vitro and in vivo, was shown to be inhibited by application of the electric fields. In the clinical setting, electric fields are available for treatment of brain tumors, specifically glioblastoma (GBM), through a portable device producing so-called tumor treating fields (TTF). Clinical trials conducted in patients with recurrent and newly diagnosed GBM indicated that this novel treatment modality is active and associated with minimal toxicity. This manuscript will review the available evidence supporting the use of TTF in neuro-oncologic practice.
已知电场会产生生物学效应。根据特定频率，它们可以刺激愈合、直接损伤组织或产生抗有丝分裂活性。已表明100 - 300千赫兹的频率会扰乱有丝分裂并导致细胞死亡。体外和体内癌细胞系的生长均显示可通过施加电场来抑制。在临床环境中，电场可通过一种产生所谓肿瘤治疗电场（TTF）的便携式设备用于治疗脑肿瘤，特别是胶质母细胞瘤（GBM）。在复发性和新诊断的GBM患者中进行的临床试验表明，这种新型治疗方式有效且毒性极小。本手稿将综述支持在神经肿瘤学实践中使用TTF的现有证据。
