α-肾上腺素能激动剂局部及动脉内给药后对离体灌注兔眼的降压作用。

Hypotensive effects after topical and intra-arterial administration of alpha-adrenergic agonists in isolated perfused rabbit eyes.

作者信息

van Pinxteren P C

出版信息

Ophthalmic Res. 1985;17(6):349-53. doi: 10.1159/000265400.

Abstract

The influence of nonselective and selective alpha-adrenergic agonists on intraocular pressure (IOP) was studied in isolated arterially perfused rabbit eyes. Drugs were given intra-arterially or topically. With either route of administration, no initial hypertensive phase was observed after l-epinephrine, l-norepinephrine, l-phenylephrine (alpha 1), or methoxamine (alpha 1), but there was an immediate ocular hypotensive effect. The alpha 2-agonist B-HT 920 caused a nonsignificant 1 mm Hg fall in IOP.

摘要

在离体动脉灌注兔眼中研究了非选择性和选择性α-肾上腺素能激动剂对眼压（IOP）的影响。药物通过动脉内或局部给药。无论采用哪种给药途径，在给予l-肾上腺素、l-去甲肾上腺素、l-去氧肾上腺素（α1）或甲氧明（α1）后均未观察到初始高血压期，但有立即的眼压降低作用。α2-激动剂B-HT 920使眼压下降1 mmHg，差异无统计学意义。