1 Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomedica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) , Barcelona, Spain .
2 Department of Cardiovascular and Metabolic Diseases, IRCCS Multimedica , Milan, Italy .
Diabetes Technol Ther. 2017 Sep;19(9):493-497. doi: 10.1089/dia.2017.0135. Epub 2017 Jun 30.
In the management of diabetes, postprandial glycemia (PPG) is usually targeted 2 h after the start of meal. Recent evidences, however, suggest that the value of glycemia at 1 h during an oral glucose tolerance test (OGTT) is a stronger predictor for developing diabetes than the value at 2 h and that it is an independent risk factor for cardiovascular disease. Studies in cells, animals, and humans suggest that 1-h high glucose is a sufficient stimulus for increasing several cardiovascular risk factors, such as inflammation, thrombosis, and endothelial dysfunction, with oxidative stress generation as the possible pathogenetic factor. One-hour glucose might be more dangerous than that at 2 h simply because glycemia is higher at 1 h, during an OGTT and postmeal. The new drugs, able to target better 1 h glycemia and the new noninvasive technologies for glucose monitoring, nowadays may help to change the therapeutic paradigm of targeting PPG at 2 h.
在糖尿病管理中，通常以餐后 2 小时的血糖（PPG）作为目标。然而，最近的证据表明，口服葡萄糖耐量试验（OGTT）1 小时的血糖值比 2 小时的血糖值更能预测糖尿病的发生，而且是心血管疾病的独立危险因素。细胞、动物和人类的研究表明，1 小时高血糖足以增加多种心血管危险因素，如炎症、血栓形成和内皮功能障碍，氧化应激的产生可能是其发病机制。1 小时高血糖可能比 2 小时高血糖更危险，仅仅是因为在 OGTT 和餐后 1 小时血糖更高。目前，能够更好地控制 1 小时血糖的新型药物和新型非侵入性血糖监测技术，可能有助于改变以 2 小时 PPG 为目标的治疗模式。
