Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Eur J Pharmacol. 2017 Oct 5;812:9-17. doi: 10.1016/j.ejphar.2017.06.036. Epub 2017 Jun 27.
Asthma, a complex pulmonary allergic disease, major therapy is applied of drugs to control the disease, but quickly recur after the drugs are stopped. In patients with severe asthma may show steroid resistance and would benefit from the development of novel therapeutic drugs. Ovatodiolide, a unique macrocyclic diterpenoid isolated from Anisomeles indica, showed therapeutic potential for the treatment of allergic asthma. As a model of allergic inflammation, we used ovalbumin (OVA)-immunized mice, which displayed T helper cell type 2 (T2) cytokine expression in bronchoalveolar lavage fluid (BALF), as well as airway inflammation and hyperresponsiveness (AHR). The results showed that ovatodiolide suppressed T2 activation, including cell proliferation and production of the T2 related cytokines, interleukin (IL)-4, IL-5, IL-13, IL-33, eosinophil chemotactic protein (eotaxin), and also reduced airway hyperresponsiveness. In this study, ovatodiolide inhibited allergic asthma through downregulation of T2 responses in a murine model of asthma.
哮喘是一种复杂的肺部过敏性疾病，主要治疗方法是应用药物来控制疾病，但停药后会迅速复发。在严重哮喘患者中可能表现出类固醇耐药性，因此需要开发新型治疗药物。从山蒟中分离得到的独特大环二萜欧巴卡丁内酯具有治疗过敏性哮喘的潜力。作为过敏炎症的模型，我们使用卵清蛋白（OVA）免疫的小鼠，其支气管肺泡灌洗液（BALF）中显示 T 辅助细胞 2（T2）细胞因子表达，以及气道炎症和高反应性（AHR）。结果表明，欧巴卡丁内酯抑制 T2 激活，包括细胞增殖和 T2 相关细胞因子白细胞介素（IL）-4、IL-5、IL-13、IL-33、嗜酸性粒细胞趋化蛋白（eotaxin）的产生，还降低了气道高反应性。在这项研究中，欧巴卡丁内酯通过下调哮喘小鼠模型中的 T2 反应来抑制过敏性哮喘。
