Ochoa Sebastian, Cheng Kyle, Fleury Christine M, Luccioli Stefano, Bellanti Joseph A
Allergy Asthma Proc. 2017 Jul 1;38(4):322-327. doi: 10.2500/aap.2017.38.4042.
A 28-year-old Hispanic woman was admitted to the hospital with fever, sore throat, arthralgia, and a generalized rash of 2 weeks' duration. Her medical history was significant for various food and medication allergies. Multiple antibiotics were given for suspected infection, and she subsequently developed a new skin rash, acute liver injury, eosinophilia, and pancytopenia. Additional studies showed hypertriglyceridemia; elevated interleukin-2 receptor levels; absent natural killer cell activity; and hemophagocytosis in skin, liver, and bone marrow biopsy specimens. Treatment with intravenous immunoglobulin and steroids resulted in complete remission.
一名28岁的西班牙裔女性因发热、咽痛、关节痛以及持续2周的全身性皮疹入院。她有多种食物和药物过敏的病史。因怀疑感染给予了多种抗生素治疗，随后她出现了新的皮疹、急性肝损伤、嗜酸性粒细胞增多和全血细胞减少。进一步检查显示高甘油三酯血症；白细胞介素-2受体水平升高；自然杀伤细胞活性缺失；皮肤、肝脏和骨髓活检标本中有噬血细胞现象。静脉注射免疫球蛋白和类固醇治疗后完全缓解。
