Hu Tingting, Su Fengxi, Jiang Wenguo, Dart D Alwyn
Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Henry Wellcome Building, Heath Park, Cardiff, U.K.
Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.
Anticancer Res. 2017 Jul;37(7):3441-3451. doi: 10.21873/anticanres.11712.
To examine the expression and function of activin receptor-like kinase 7 (ALK7) in breast cancer, its association with disease prognosis, and its impact on breast cancer cell function.
A cohort of patients with breast cancer were examined for ALK7 expression in association with pathological and clinical aspects. In vitro cell assays of ALK7 were investigated using an expression plasmid.
Overall higher levels of ALK7 transcripts were seen in the breast cancer samples vs. normal tissue. However, within the cancer cohort, lower levels of ALK7 transcript were associated with poor prognosis. Patients with lower expression of ALK7 also had shorter survival. Overexpression of ALK7 reduced proliferation and adhesion of breast cancer cells in vitro. We found that overexpressed ALK7 had complex effects on the MCF-7 cell sensitivity to chemotherapy drugs.
Decreased expression of ALK7 in breast cancer is correlated with poor prognosis. ALK7 is a negative regulator of adhesion and proliferation of breast cancer cells. This suggests that ALK7 is a potential tumor suppressor in breast cancer.
研究激活素受体样激酶7（ALK7）在乳腺癌中的表达及功能、其与疾病预后的关系以及对乳腺癌细胞功能的影响。
对一组乳腺癌患者进行ALK7表达检测，并结合病理和临床情况进行分析。使用表达质粒对ALK7进行体外细胞实验研究。
与正常组织相比，乳腺癌样本中ALK7转录本的总体水平较高。然而，在癌症队列中，ALK7转录本水平较低与预后不良相关。ALK7表达较低的患者生存期也较短。ALK7过表达在体外可降低乳腺癌细胞的增殖和黏附能力。我们发现过表达的ALK7对MCF-7细胞对化疗药物的敏感性有复杂影响。
乳腺癌中ALK7表达降低与预后不良相关。ALK7是乳腺癌细胞黏附和增殖的负调节因子。这表明ALK7是乳腺癌中一种潜在的肿瘤抑制因子。
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