α-乙酰半乳糖胺基转移酶-6的表达与子宫内膜癌中细胞黏附分子的表达相关。

Expression of -Acetylgalactosaminyltransferase-6 Is Related to Expression of Cell Adhesion Molecules in Endometrial Cancer.

作者信息

Kurita Tomoko, Thi Thuy Nguyen, Koi Chiho, Murakami Midori, Kagami Seiji, Izumi Hiroto, Hachisuga Toru

机构信息

Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan

Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.

出版信息

Anticancer Res. 2017 Jul;37(7):3905-3910. doi: 10.21873/anticanres.11772.

DOI:10.21873/anticanres.11772

PMID:28668893

Abstract

BACKGROUND

The aberrant glycosylation of mucin type O-glycans is thought to be associated with functional alteration of cancer cells, including adhesive properties, as well as their potential for invasion and metastasis. Positive expression of N-acetylgalactosaminyltransferase-6 (GalNAc-T6) may also be a marker for aberrant O-glycans in carcinogenesis. We previously reported that over-expression of GalNAc-T6 had a strong association with endometrial cell invasion ability in vitro.

MATERIALS AND METHODS

This study investigated the relationship between GalNAc-T6 expression and cell adhesion molecules in 218 endometrial carcinomas by immunohistochemistry.

RESULTS

Expression of GalNAc-T6 was found to be significantly related to expression of E-cadherin. Positive expression of GalNAc-T6 was significantly associated with better histological grade and good clinical prognosis of patients, but positive E-cadherin and β-catenin expression were not significantly associated with improved overall survival.