Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Clin Transl Oncol. 2022 Oct;24(10):1865-1880. doi: 10.1007/s12094-022-02858-z. Epub 2022 Jun 25.
Endometrial cancer (EC) is one of the most common tumors in the female reproductive system, which seriously threatens women's health, particularly in developed countries. 13% of the patients with EC have a poor prognosis due to recurrence and metastasis. Therefore, identifying good predictive biomarkers and therapeutic targets is critical to enable the early detection of metastasis and improve the prognosis. For decades, extensive studies had focused on glycans and glycoproteins in the progression of cancer. The types of glycans that are covalently attached to the polypeptide backbone, usually via nitrogen or oxygen linkages, are known as N‑glycans or O‑glycans, respectively. The degree of protein glycosylation and the aberrant changes in the carbohydrate structures have been implicated in the extent of tumorigenesis and reported to play a critical role in regulating tumor invasion, metabolism, and immunity. This review summarizes the essential biological role of glycosylation in EC, with a focus on the recent advances in glycomics and glycosylation markers, highlighting their implications in the diagnosis and treatment of EC.
子宫内膜癌（EC）是女性生殖系统最常见的肿瘤之一，严重威胁着妇女的健康，尤其是在发达国家。由于复发和转移，约 13%的 EC 患者预后不良。因此，确定良好的预测生物标志物和治疗靶点对于实现转移的早期检测和改善预后至关重要。几十年来，人们广泛研究了糖链和糖蛋白在癌症进展中的作用。通过氮或氧键连接到多肽主链上的糖链类型分别称为 N-糖链或 O-糖链。蛋白质糖基化的程度和碳水化合物结构的异常变化与肿瘤发生的程度有关，并被报道在调节肿瘤侵袭、代谢和免疫方面发挥着关键作用。本综述总结了糖基化在 EC 中的重要生物学作用，重点介绍了糖组学和糖基化标志物的最新进展，强调了它们在 EC 的诊断和治疗中的意义。
