Zacharko R M, Wishart T B, Loew F M
J Comp Physiol Psychol. 1979 Feb;93(1):140-50. doi: 10.1037/h0077585.
The anorexic consequence of thiamin deprivation was investigated in ventromedial hypothalamic (VMH) hyperphagic rats under either high-fat or low-fat thiamin-free diet conditions. The low-fat diet maintained feeding significantly longer in thiamin-deprived VMH rats than in intact rats, whereas the hig-fat diet sustained feeding in thiamin-deficient intact rats and accelerated anorexia onset in vitamin B1 deprived VMH rats. This effect was noted under both ad lib and pair-feeding conditions. Thiamin-deprived VMH rats subjected to weight control developed anorexia sooner than intact subjects regardless of the diet employed. The VMH rats fed a high-fat diet failed to resume feeding after thiamin readministration, which was interpreted as a permanent aversion to this diet. The relation between dietary intake and conditioned taste aversion is discussed with reference to the VMH and intact rat.
在高脂或低脂无硫胺饮食条件下，研究了硫胺缺乏对腹内侧下丘脑（VMH）食欲亢进大鼠的厌食影响。与正常大鼠相比，硫胺缺乏的VMH大鼠在低脂饮食下进食时间显著延长，而高脂饮食则使硫胺缺乏的正常大鼠持续进食，并加速了维生素B1缺乏的VMH大鼠的厌食发作。在自由采食和配对喂养条件下均观察到这种效应。无论采用何种饮食，体重得到控制的硫胺缺乏VMH大鼠比正常大鼠更早出现厌食。高脂饮食喂养的VMH大鼠在重新给予硫胺后未能恢复进食，这被解释为对这种饮食的永久性厌恶。结合VMH大鼠和正常大鼠讨论了饮食摄入与条件性味觉厌恶之间的关系。
