Ghosh A K
Curr Med Res Opin. 1985;9(10):691-6. doi: 10.1185/03007998509109652.
Twenty-six ambulant elderly patients (age range 62 to 78 years) whose blood pressure control was inadequate with either beta-blocker or diuretic monotherapy were studied in a randomized, prospective double-blind comparison of atenolol (50 mg), amiloride (5 mg) with hydrochlorothiazide (50 mg), and these two treatments combined. Blood pressures were measured at least 24 hours after a single daily dose. The combined therapy was more effective in reducing lying (p less than 0.01) and standing (p less than 0.05) systolic blood pressure than either beta-blocker or diuretic alone. Combined therapy was more effective than diuretic on lying (p less than 0.05) or standing blood pressure (p less than 0.01). There was little difference in blood pressure control between beta-blocker and diuretic therapy. Side-effect complaints were similar on beta-blocker (5 complaints) and diuretic (7) and appeared to be additive on combined treatment (12). Diuretic treatment alone or in combination after the 1-month randomized periods produced shifts in some biochemical parameters (creatinine, urea, urate, sodium) in this older population of treated hypertensives, but clinically significant alteration in serum potassium levels was not seen.
26例血压控制不佳的老年门诊患者（年龄62至78岁），使用β受体阻滞剂或利尿剂单一疗法治疗效果欠佳，对这些患者进行了一项随机、前瞻性双盲对照研究，比较阿替洛尔（50毫克）、阿米洛利（5毫克）与氢氯噻嗪（50毫克）以及这两种治疗方法联合使用的效果。每日单次给药后至少24小时测量血压。联合治疗在降低卧位（p<0.01）和立位（p<0.05）收缩压方面比单独使用β受体阻滞剂或利尿剂更有效。联合治疗在降低卧位（p<0.05）或立位血压（p<0.01）方面比利尿剂更有效。β受体阻滞剂和利尿剂治疗在血压控制方面差异不大。β受体阻滞剂组（5例）和利尿剂组（7例）的副作用投诉相似，联合治疗组（12例）似乎有相加现象。在1个月的随机治疗期后，单独使用利尿剂或联合使用利尿剂均使该老年高血压患者群体的一些生化参数（肌酐、尿素、尿酸、钠）发生了变化，但未观察到血清钾水平有临床意义的改变。
