1Department of Medicine,McMaster University,Hamilton,Ontario,Canada.
2Department of Human Health and Nutritional Sciences,University of Guelph,Guelph,Ontario,Canada.
Can J Neurol Sci. 2017 Sep;44(5):572-576. doi: 10.1017/cjn.2017.204. Epub 2017 Jul 3.
Preliminary studies have supported the utility of exercise as a treatment for Charcot-Marie-Tooth disease (CMT) patients. Despite being the most common inherited neuropathy, there remains a paucity of guidelines for CMT management.
A retrospective chart review was performed on 297 CMT patients. Self-reported exercise and strength results from standardized dynamometer testing were obtained from adult patients' first visits. Values were converted and analyzed based on previously reported age- and sex-matched normative values.
Participants with CMT2 had greater strength values than those with CMT1 in hand grip, elbow flexion, and dorsiflexion (p<0.05). Participants with CMT1 and CMT2 who exercised were statistically significantly stronger in elbow flexion and dorsiflexion than those who did not exercise.
These preliminary results suggest that self-directed exercise is associated with greater strength in CMT patients of both CMT1 and CMT2 subtypes. Self-directed exercise may be a convenient, sustainable, and effective method of improving strength and decreasing disability in this population. Future research should explore the type of exercise prescription that best addresses the needs of the CMT population.
初步研究支持运动作为治疗腓骨肌萎缩症（CMT）患者的一种方法。尽管它是最常见的遗传性周围神经病，但对于 CMT 的管理仍然缺乏指南。
对 297 名 CMT 患者进行了回顾性图表审查。从成年患者的首次就诊中获得了自我报告的运动和力量测试结果。根据以前报告的年龄和性别匹配的正常值对数值进行了转换和分析。
手部握力、肘部弯曲和脚背伸展方面，CMT2 参与者的力量值大于 CMT1 参与者（p<0.05）。与未锻炼的患者相比，进行锻炼的 CMT1 和 CMT2 参与者在肘部弯曲和脚背伸展方面的力量明显更强。
这些初步结果表明，自我指导的运动与 CMT1 和 CMT2 两种亚型的 CMT 患者的力量增强有关。自我指导的运动可能是改善该人群力量和减少残疾的一种方便、可持续且有效的方法。未来的研究应探索最能满足 CMT 人群需求的运动处方类型。
