Agrawal Archi, Pantvaidya Gouri, Murthy Vedang, Prabhash Kumar, Bal Munita, Purandare Nilendu, Shah Sneha, Rangarajan Venkatesh
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India.
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
World J Nucl Med. 2017 Jul-Sep;16(3):197-201. doi: 10.4103/1450-1147.207274.
To evaluate the accuracy of fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in staging and restaging of patients with mucosal melanomas (MM) of head and neck. Patients who underwent PET/CT at our institution, with a biopsy proven diagnosis of MM of the head and neck between March 2006 and December 2013 were included in the study. Nineteen patients with MM of the nasal cavity, paranasal sinuses, and oral cavity were included, of which 12 were for staging and seven for restaging. PET/CT had 100% sensitivity (SN), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV) for detection of the primary. SN of 91.7%, SP of 100%, PPV of 100%, and NPV of 87.5% were seen for nodal metastases. For distant metastases, SN of 85.7%, SP of 100%, PPV of 100%, and NPV of 92.3% were noted. The disease was upstaged from loco-regional to metastatic in 32% leading to treatment change in 25% in the staging group and 43% in the restaging group. PET/CT demonstrates good overall accuracy in evaluation of patients with MM of the head and neck. The main strength of PET/CT lies in detection of distant metastatic disease due to extended whole-body field of view.
评估氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）对头颈部黏膜黑色素瘤（MM）患者进行分期及再分期的准确性。纳入2006年3月至2013年12月期间在我院接受PET/CT检查、经活检确诊为头颈部MM的患者。纳入19例鼻腔、鼻窦及口腔MM患者，其中12例用于分期，7例用于再分期。PET/CT检测原发灶的灵敏度（SN）、特异度（SP）、阳性预测值（PPV）和阴性预测值（NPV）均为100%。检测区域淋巴结转移的SN为91.7%，SP为100%，PPV为100%，NPV为87.5%。检测远处转移的SN为85.7%，SP为100%，PPV为100%，NPV为92.3%。在分期组中，32%的患者疾病分期从局部区域期上调至转移期，导致25%的患者治疗方案改变；在再分期组中，这一比例为43%。PET/CT在评估头颈部MM患者时总体准确性良好。PET/CT的主要优势在于其全身视野范围广，能够检测远处转移病灶。
