Khan Muhammad Aleem, Malik Nadeem, Khan Kamran Hakeem, Shahzad Muhammad Faheem
Department of Nuclear Medicine, Nuclear Medicine, Oncology and Radiotherapy Institute, Islamabad, Pakistan.
Department of Family Medicine, Holy Family Hospital, Rawalpindi, Pakistan.
World J Nucl Med. 2017 Jul-Sep;16(3):202-205. doi: 10.4103/1450-1147.207277.
The aim of the current study was to determine the frequency of carcinoma thyroid among patients presenting with goiter and its association with preoperative serum thyroid-stimulating hormone (TSH) levels. A total of 73 ( = 73) adult patients of either gender with solitary solid cold nodule and multinodular goiter with predominant solid cold nodule were analyzed. All surgically resected samples were sent for histopathology. The frequency of thyroid cancer and its subtypes was noted and tested for association with preoperative serum TSH values. Thyroid cancer was diagnosed in 26% ( = 19) of the patients. In patients with thyroid cancer ( = 19), 73.7% ( = 14) were diagnosed with papillary thyroid cancer and 26.3% ( = 5) were diagnosed with follicular thyroid cancer. Presence of thyroid cancer was found to be significantly associated with preoperative higher mean TSH values ( < 0.05). Higher preoperative serum TSH levels may be useful in predicting thyroid cancer in nodular thyroid disease. Further studies are recommended with different cutoff values of serum TSH and its association with the development and progression of thyroid cancer.
本研究的目的是确定甲状腺肿患者中甲状腺癌的发生率及其与术前血清促甲状腺激素（TSH）水平的关联。共分析了73例（n = 73）患有孤立实性冷结节和以实性冷结节为主的多结节性甲状腺肿的成年患者，无论性别。所有手术切除的样本均送去做组织病理学检查。记录甲状腺癌及其亚型的发生率，并检测其与术前血清TSH值的关联。26%（n = 19）的患者被诊断为甲状腺癌。在甲状腺癌患者（n = 19）中，73.7%（n = 14）被诊断为乳头状甲状腺癌，26.3%（n = 5）被诊断为滤泡状甲状腺癌。发现甲状腺癌的存在与术前较高的平均TSH值显著相关（P < 0.05）。术前较高的血清TSH水平可能有助于预测结节性甲状腺疾病中的甲状腺癌。建议进一步研究血清TSH的不同临界值及其与甲状腺癌发生和进展的关联。
