Zemlin Annalise E, Matsha Tandi E, Kengne Andre P, Hon Gloudina, Erasmus Rajiv T
Division of Chemical Pathology, Faculty of Medicine and Health Sciences, National Health Laboratory Service (NHLS) and University of Stellenbosch, Cape Town, South Africa.
Department of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa.
J Med Biochem. 2016 Nov 2;35(4):416-427. doi: 10.1515/jomb-2016-0024. eCollection 2016 Oct.
High molecular weight (HMW) adiponectin has antiatherogenic, antiinflammatory and antidiabetic properties and these effects have been linked to its effect on high density lipoprotein cholesterol (HDL-c). Single nucleotide polymorphisms (SNPs) in the adiponectin gene influence adiponectin levels. We examined the relationship between HMW-adiponectin levels and cardiometabolic traits in normo- and hyperglycemic mixed ancestry South Africans and correlated these levels to two common polymorphisms.
HMW-adiponectin was determined in 101 subjects from the Cape Town Bellville South community-based study on a mixed ancestry population. Comparisons were made between individuals with normo- and hyperglycemia. Two common SNPs, SNPs rs17300539 and rs266729, known to affect adiponectin levels were also tested for. Levels of HMW-adiponectin were then correlated with cardiometabolic traits in all groups.
Levels of HMW-adiponectin were not significantly different in the normo- and hyperglycemic groups (median 11.6 vs. 10.5 μg/mL, p=0.3060) and in men and women (8.44 vs. 11.34 μg/mL, p=0.67). SNPs rs17300539 and rs266729 did not influence levels of HMW-adiponectin. Robust correlation analyses revealed a significant positive correlation between HMW-adiponectin and HDL-c (r=0.45; 95%CI: 0.27-0.59), similarly in normo- and hyperglycemic participants (p > 0.99). This association was substantially attenuated in robust linear regressions adjusted for age, gender and adiposity.
Adiponectin levels in this population were not determined by the commonest SNPs of the adiponectin gene, were unaffected by glycemic status; but were significantly correlated with HDL-c levels. Previous studies have attributed some of the beneficial effects of adiponectin to its effect on HDL-c.
高分子量（HMW）脂联素具有抗动脉粥样硬化、抗炎和抗糖尿病特性，这些作用与其对高密度脂蛋白胆固醇（HDL-c）的影响有关。脂联素基因中的单核苷酸多态性（SNP）会影响脂联素水平。我们研究了正常血糖和高血糖的南非混合血统人群中HMW-脂联素水平与心脏代谢特征之间的关系，并将这些水平与两个常见多态性进行关联。
在开普敦贝尔维尔南区基于社区的混合血统人群研究中，对101名受试者测定了HMW-脂联素。对正常血糖和高血糖个体进行了比较。还检测了已知会影响脂联素水平的两个常见SNP，即SNP rs17300539和rs266729。然后将所有组中HMW-脂联素水平与心脏代谢特征进行关联。
正常血糖组和高血糖组的HMW-脂联素水平无显著差异（中位数分别为11.6和10.5μg/mL，p = 0.3060），男性和女性之间也无显著差异（分别为8.44和11.34μg/mL，p = 0.67）。SNP rs17300539和rs266729不影响HMW-脂联素水平。稳健的相关性分析显示HMW-脂联素与HDL-c之间存在显著正相关（r = 0.45；95%CI：0.27 - 0.59），正常血糖和高血糖参与者中情况类似（p > 0.99）。在根据年龄、性别和肥胖程度进行调整的稳健线性回归中，这种关联显著减弱。
该人群中的脂联素水平不由脂联素基因最常见的SNP决定，不受血糖状态影响，但与HDL-c水平显著相关。先前的研究将脂联素的一些有益作用归因于其对HDL-c的影响。
